Quality of life among post-menopausal women due to oxidative stress boosted by dysthymia and anxiety

Abstract

BackgroundMenopause is the onset of aging in women. During this process, some women experience physical changes that may impact upon their psychological and social status, also affecting their quality of life. Furthermore, several psychological changes following menopause have been shown to act as pro-oxidant, but the association between the psychological status that modify the quality of life and oxidative stress in postmenopausal women is still unclear. The aim of this study was to determinate the relationship between oxidative stress with psychological disturbances, low self-esteem, depressive mood and anxiety, and quality of life in the postmenopausal women.MethodsWe carried out a cross-sectional study with101 premenopausal and 101 postmenopausal women from Mexico City. As markers of oxidative stress we measured plasma lipoperoxide levels, erythrocyte superoxide dismutase and glutathione peroxidase activities, and total antioxidant status. We calculate a stress score as global oxidative stress status, with cut-off values for each parameter; this score range from 0 to 6, representing the severity of markers modifications. All the women were rated using the Coopersmith Self-Esteem Inventory, the Zung Self-Rating Anxiety and the Zung Self-Rating Depression Scales, and the WHO Quality of Life-brief.ResultsThe postmenopausal women with low quality of life in the WHO Quality of Life-brief and their subscales had higher stress score compared with premenopausal women with high quality of life (p < 0.05). We found a positive correlation among lipoperoxide levels and Zung Self-Rating Anxiety and Zung Self-Rating Depression score (r = 0.226 and r = 0.173, respectively, p < 0.05), and a negative correlation with WHO Quality of Life-brief scores (r = −0.266, p < 0.01) in postmenopausal women. Multiple linear regression analysis revealed that average lipoperoxide levels increase by 0.0007 μmol/L for every 1-point increase in the Coopersmith Self-Esteem Inventory and by 0.001 μmol/L for every 1-point decrease in the WHO Quality of Life-brief, after adjusted for pro-oxidant factors. Zung Self-Rating Anxiety and Zung Self-Rating Depression Scales scores also contribute to increase lipoperoxides levels, but not significant.ConclusionOur findings suggest that oxidative stress is increased in postmenopausal women with psychological disturbances and low quality of life.

Correlates of long-acting reversible contraception uptake among rural women in Guatemala

“…Long-acting reversible contraception (LARCs), including intrauterine devices (IUDs) and sub-dermal implants, offer a safe and cost-effective alternative that could help women space or limit births [ 2 , 4 , 5 ]. While their use is slowly rising in some developed nations [ 6 ], they remain uncommon in most LMICs [ 1 , 2 , 7 , 8 ].…”

“…In addition, demographic attributes of users, including younger age [ 11 ], and future fertility plans, such shorter interval to next desired pregnancy [ 13 ], are also associated with lower LARC uptake in previously published studies. Qualitative work has also documented pervasive myths about IUDs and implants among both patients [ 7 , 14 ] and medical providers [ 15 ]. These—along with the side effect profiles and changes in menstruation inherent to the methods—may lead family planning clients to simply prefer injectables and COCs over implants and IUDs despite their increased efficacy.…”

Association between hot flashes severity and oxidative stress among Mexican postmenopausal women: a cross-sectional study

“…Although some oxidative damage markers are used to evaluate OS, such as 4-HNE and isoprostanes, the measurement of antioxidant markers has not always been consistent, therefore, our research group had proposed an index to integrate both processes. This index has been used in different studies and shown to be useful for measuring OS [37-39].…”

“…Besides, it is known that the psycho-neuro-endocrine change and vasomotor symptoms during menopausal transition affect self-esteem, mood states and therefore quality of life [40,41]. Furthermore, depressive mood, anxiety and insomnia are considered pro-oxidant factors as well as the severe discomfort felt, and these factors can increase OS [8,39,42,43]. Therefore, we analyze a possible correlation between SS and menopausal symptoms scores to assess which alteration was related with OS.…”

Efecto del liofilizado de hojas de Mangifera indica L. “mango kent”, sobre memoria espacial y la lipoperoxidación en membranas neuronales de Rattus norvegicus Sprague Dawley ovariectomizadas

“…El hito más importante de esta transición natural se da con la aparición de la menopausia, definida como el último periodo menstrual que una mujer tiene, y es diagnosticado después de un periodo de un año sin aparición de menstruación (2) . Este proceso fisiológico complejo es causado por la disminución de la producción de 17β-estradiol por los ovarios y trae como consecuencia una serie de cambios fisiológicos que pueden interferir con la capacidad para hacer frente a un nuevo estado psicológico y social, además de afectar la calidad de vida (3,4) .…”