Quality of life after tonsillectomy versus azithromycin

Abstract

BackgroundRecurrent tonsillitis is a common disease with marked evidence of affecting children quality of life (QOL) such as their progression in school and increased burden to extended families. The aim of this study was to compare the QOL outcomes after conventional dissection tonsillectomy versus azithromycin treatment in controlling recurrent tonsillitis.MethodsA double-blind, randomized clinical trial was carried out in 184 children with recurrent tonsillitis randomly divided into two groups: Group A was subjected to conventional dissection tonsillectomy, whereas Group B received single 250 mg (children ≤25 kg) and 500 mg (children ≥25 kg) of oral azithromycin once weekly.ResultsThere were no significant differences between the groups with regard to ear, nose, and throat infections during the 5-year follow-up. Better QOL was observed in both groups when compared with the pretreatment, but similar QOL in both groups QOL after treatment.ConclusionAzithromycin is an effective method as a prophylaxis against recurrent tonsillitis with a great benefit for better QOL outcomes.

<p>Pilot study to explore the prophylactic efficacy of oral probiotic Streptococcus salivarius K12 in preventing recurrent pharyngo-tonsillar episodes in pediatric patients</p>

“…An improvement in the quality-of-life after tonsillectomy has been reported in subjects undergoing repeated cycles of antibiotic therapy, but no randomized controlled trials evaluating the effect of tonsillectomy on the general well-being, development, and behavior of the child are available. These measures, however, represent important treatment outcomes to be inserted in future clinical research 4,5…”

Echinacea can help with Azithromycin in prevention of recurrent tonsillitis in children

“…Tonsillectomy morbidity has high impact on the QOL of patients such as socioeconomic factors and increased burden to parents from the suffering of the child. 18 Tonsillectomy should not be the only solution as there is a possibility of immunological deficit as the function of tonsils in the immune system is not completely clear as an important constituent of the upper respiratory tract defense system. 19 On the other hand, patients who undergone tonsillectomy are at high risk of developing bronchial asthma 20 and Crohn's disease 21 .…”

“…Patients received AZT alone had significant less tonsillitis attacks and less severe symptoms than patients who didn't receive any prophylaxis during the same period of the study. El Hennawi et al 18 in their study concluded that AZT is effective in prophylaxis against recurrent tonsillitis with a great benefit for better QOL compared to patients who had tonsillectomy, however; they used the prophylactic regimen of rheumatic fever prevention (once weekly AZT) 23 and they didn't include a control group in their study. Casey and Pichichero 24 reported that AZT treatment for GABHS tonsillopharyngitis in children and adults is more effective than other treatment regimens in providing clinical cure of tonsillopharyngitis.…”

Normative tonsillectomy outcome inventory 14 values as a decision-making tool for tonsillectomy

“…The lifetime prevalence of common RT is 7-11% [9]. Only a few studies have addressed whether recurrent tonsillopharyngitis affects QOL in adults [1,5,6,10,11], although this has been well-studied in children [6,7,[12][13][14][15][16][17][18][19][20][21][22][23][24]. In 2012, Skevas et al introduced the Tonsillectomy Outcome Inventory 14 , which was the first worldwide-validated instrument to measure disease-specific QOL in adults with RT [25].…”

“…Previous studies have shown that tonsillectomy is associated with improved health-related quality of life (HR-QOL) [ 1 , 2 , 4 , 5 ], reduced medication consumption, less time off work, and fewer visits to the physician [ 6 ]. In another study, 75% of tonsillectomies for RT resulted in postoperative pharyngitis and upper respiratory tract infections [ 7 ].…”