Echinacea can help with Azithromycin in prevention of recurrent tonsillitis in children

Awad, Osama G. Abdel-Naby

doi:10.1016/j.amjoto.2019.102344

Cited by 7 publications

(10 citation statements)

References 29 publications

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“…Taylor et al (2003) [42] and Sumer et al (2023) [37] allowed for a repetitive therapy of up to three episodes over a prolonged observational time [37,42]. Six prevention studies administered Echinacea for a shorter period of equal or less than one month [21,24,25], three of which employed an artificial inoculation method [16,31,33], whereas the remaining studies employed longer treatment periods between six weeks to five months [14,15,[17][18][19][20]22,23,[26][27][28][29][30]32,34,42]. Awad et al applied an interval preventive therapy of 6 × 10 days throughout half a year [29].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Six prevention studies administered Echinacea for a shorter period of equal or less than one month [21,24,25], three of which employed an artificial inoculation method [16,31,33], whereas the remaining studies employed longer treatment periods between six weeks to five months [14,15,[17][18][19][20]22,23,[26][27][28][29][30]32,34,42]. Awad et al applied an interval preventive therapy of 6 × 10 days throughout half a year [29]. Weber et al [35] presented a sub-analysis of the work by Taylor et al [42], giving information on recurrent infections under Echinacea or placebo therapy.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The majority of the 39 comparisons involved lipophilic Echinacea purpurea extracts based on alcoholic extractions, glycerol or hypercritical CO 2 extractions [14,15,[17][18][19]22,[25][26][27]30,32,[36][37][38][39]. Seven preparations contained Echinacea purpurea pressed-juices (hydrophilic) [21,23,24,31,33,40,42], whereas four preparations contained dried, powdered or unspecified Echinacea [16,28,29,43]. As anticipated, a great variety of Echinacea preparations were included in this analysis with the aim to investigate overarching evidence of activity for the medicinal plant.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Echinacea Reduces Antibiotics by Preventing Respiratory Infections: A Meta-Analysis (ERA-PRIMA)

Gancitano,

Mucci,

Stange

et al. 2024

Antibiotics

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Respiratory tract infections (RTIs) are the leading cause of antibiotic prescriptions, primarily due to the risk for secondary bacterial infections. In this study, we examined whether Echinacea could reduce the need for antibiotics by preventing RTIs and their complications, and subsequently investigated its safety profile. A comprehensive search of EMBASE, PubMed, Google Scholar, Cochrane DARE and clinicaltrials.gov identified 30 clinical trials (39 comparisons) studying Echinacea for the prevention or treatment of RTIs in 5652 subjects. Echinacea significantly reduced the monthly RTI occurrence, risk ratio (RR) 0.68 (95% CI 0.61–0.77) and number of patients with ≥1 RTI, RR = 0.75 [95% CI 0.69–0.81] corresponding to an odds ratio 0.53 [95% CI 0.42–0.67]. Echinacea reduced the risk of recurrent infections (RR = 0.60; 95% CI 0.46–0.80), RTI complications (RR = 0.44; 95% CI 0.36–0.54) and the need for antibiotic therapy (RR = 0.60; 95% CI 0.39–0.93), with total antibiotic therapy days reduced by 70% (IRR = 0.29; 95% CI 0.11–0.74). Alcoholic extracts from freshly harvested Echinacea purpurea were the strongest, with an 80% reduction of antibiotic treatment days, IRR 0.21 [95% CI 0.15–0.28]. An equal number of adverse events occurred with Echinacea and control treatment. Echinacea can safely prevent RTIs and associated complications, thereby decreasing the demand for antibiotics. Relevant differences exist between Echinacea preparations.

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

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Echinacea Reduces Antibiotics by Preventing Respiratory Infections: A Meta-Analysis (ERA-PRIMA)

Gancitano,

Mucci,

Stange

et al. 2024

Antibiotics

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“…Echinacea is a medicinal plant used in therapy and prevention of infectious diseases of the upper respiratory tract, also recently studied for the presence of bacterial endophytes influencing the biosynthesis of alkamides and caffeic acid derivatives [ 13 , 14 ]. The combined use of Echinacea with azithromycin has produced favorable outcomes in comparison to the use of azithromycin alone in pediatric patients with recurrent tonsillitis [ 15 ]. Moreover, in a clinical trial, a combination of E. purpurea has been able to alleviate the exacerbation symptoms caused by upper respiratory tract infections, a known frequent cause of exacerbations of chronic-obstructive pulmonary diseases [ 16 ].…”

Section: Introduction To Medicinal Plantsmentioning

confidence: 99%

Medicinal Plants and Their Bacterial Microbiota: A Review on Antimicrobial Compounds Production for Plant and Human Health

Castronovo

Vassallo²,

Mengoni³

et al. 2021

Pathogens

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Medicinal plants (MPs) have been used since antiquity in traditional and popular medicine, and they represent a very important source of bioactive molecules, including antibiotic, antiviral, and antifungal molecules. Such compounds are often of plant origin, but in some cases, an origin or a modification from plant microbiota has been shown. Actually, the research continues to report the production of bioactive molecules by plants, but the role of plant–endophytic interaction is emerging. Classic examples are mainly concerned with fungal endophytes; however, it has been recently shown that bacterial endophytes can also play an important role in influencing the plant metabolism related to the synthesis of bioactive compounds. In spite of this, a deep investigation on the power of MP bacterial endophytes is lacking. Here, an overview of the studies on MP bacterial microbiota and its role in the production of plant antimicrobial compounds contributing to prime host defense system and representing a huge resource for biotech and therapeutic applications is provided.

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“…The lifetime prevalence of common RT is 7-11% [9]. Only a few studies have addressed whether recurrent tonsillopharyngitis affects QOL in adults [1,5,6,10,11], although this has been well-studied in children [6,7,[12][13][14][15][16][17][18][19][20][21][22][23][24]. In 2012, Skevas et al introduced the Tonsillectomy Outcome Inventory 14 , which was the first worldwide-validated instrument to measure disease-specific QOL in adults with RT [25].…”

Section: Introductionmentioning

confidence: 99%

Normative tonsillectomy outcome inventory 14 values as a decision-making tool for tonsillectomy

Plath

Sand

Federspil

et al. 2020

Eur Arch Otorhinolaryngol

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Purpose The study aimed to determine normative values for the Tonsillectomy Outcome Inventory 14 (TOI-14) in a healthy middle-European cohort. We also compared these generated values with TOI-14 scores from a patient population with recurrent tonsillitis (RT) and explored the factorial structure of the TOI-14. Methods We systematically studied the responses of healthy individuals (reference cohort) and patients with RT (clinical cohort) to the TOI-14 survey. The reference cohort contained 1000 participants, who were recruited using the Respondi panel for market and social science research. This subsample was quoted to the population distribution of the German Microcensus and selected from a non-probability panel. Tonsillitis patients were assessed before and 6 and 12 months after tonsillectomy. Data were analysed using principal component and exploratory factor analyses. Results The PCA revealed three TOI-14 domains (physiological, psychological and socio-economic), which explained 73% of the total variance. The reference cohort perceived a good quality of life (QOL) with a TOI-14 total score of 11.8 (physiological: 8.0, psychological: 5.8, and socio-economic subscale score: 13.9). TOI-14 scores were higher in the patient cohort, indicating that the TOI-14 discriminates between patients with RT and healthy individuals with no RT. Age and female gender significantly influenced the total TOI-14 score, especially in the psychological (age) and socio-economic (gender) subscales. Conclusion We have developed a set of normative values that, together with the TOI-14, can determine the disease burden indicating tonsillectomy.

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Echinacea can help with Azithromycin in prevention of recurrent tonsillitis in children

Abstract: Journal Pre-proof J o u r n a l P r e -p r o o f 2

Cited by 7 publications

References 29 publications

Echinacea Reduces Antibiotics by Preventing Respiratory Infections: A Meta-Analysis (ERA-PRIMA)

Echinacea Reduces Antibiotics by Preventing Respiratory Infections: A Meta-Analysis (ERA-PRIMA)

Medicinal Plants and Their Bacterial Microbiota: A Review on Antimicrobial Compounds Production for Plant and Human Health

Normative tonsillectomy outcome inventory 14 values as a decision-making tool for tonsillectomy

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