Quality control of sweet medicines based on gas chromatography-mass spectrometry

Lv, Guangping; Hu, De Jin; Zhao, Jing; Li, Shao‐Ping

doi:10.5582/ddt.2015.01020

Cited by 16 publications

(2 citation statements)

References 117 publications

(125 reference statements)

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“…Based on current gas chromatography and mass spectrometry (GC-MS) is an analytical tool used to identify and quantify bioactive compounds and evaluate the quality of each secondary metabolite. Based on the quantification, the quality of a specific sample can be determined (55).…”

Section: Gc-ms Analysismentioning

confidence: 99%

A pharmacognostic approach, including phytochemical and GC-MS analysis, targeted towards the authentication of Strobilanthes jomyi P. Biju, Josekutty, Rekha & J.R.I.Wood

Suresh

Xavier²

2023

Plant Sci. Today

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The genera Strobilanthes Blume have a rich history in therapeutic culture all over the world. Asian countries like India, China, Myanmar and Thailand still use Strobilanthes genus-based medicinal preparations for various diseases. Strobilanthes jomyi is a newly discovered species from Kerala, India. Some tribal communities of Kasaragod district still use S. jomyi leaf extract as a wound healing medication. The current study aims to investigate the pharmacognostic, phytochemical and GC-MS analysis of the leaves, stems and roots of S. jomyi. The microscopic, macroscopic, organoleptic, fluorescent, phytochemicals and GC-MS analysis of the leaves, stem, and root of S. jomyi were estimated using various standard protocols. The macroscopic and microscopic characters of leaves revealed the presence of non-glandular trichomes with paracytic stomata in the leaves. The transverse section of the stem and petiole showed the presence of raphides and the root showed the presence of tannin cells. Cystoliths were observed only in the petiole. Powder morphology of leaves, stems and roots revealed the presence of fibers, trichomes, palisade cells, spiral xylem vessels, bordered pit vessels and raphides. The vegetative part of S. jomyi powder exhibited various fluorescent coloration based on numerous chemical treatments along with different tastes, smells, colors and textures by organoleptic assays. Qualitative phytochemical analysis of different vegetative parts revealed the presence of flavonoids and other phytochemicals. GC-MS study revealed that lupeol a significant bioactive compound was present in all the vegetative parts of S. jomyi. The results acquired from this study can be used for the standardization, identification, quality and purity check of plant samples.

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Section: Gc-ms Analysismentioning

confidence: 99%

A pharmacognostic approach, including phytochemical and GC-MS analysis, targeted towards the authentication of Strobilanthes jomyi P. Biju, Josekutty, Rekha & J.R.I.Wood

Suresh

Xavier²

2023

Plant Sci. Today

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“…GC has many advantages over other measurement methods. Due to its high separation power, GC has found wide application in the food industry [ 43 , 44 ] and medicine [ 45 , 46 ]. No other method allows analysis of water samples or multicomponent liquid systems with hundreds of components in such a short time.…”

Section: In Vitro Fa Measurementmentioning

confidence: 99%

Approaches to Formaldehyde Measurement: From Liquid Biological Samples to Cells and Organisms

Lipskerov

Sheshukova

Komarova

2022

IJMS

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Formaldehyde (FA) is the simplest aldehyde present both in the environment and in living organisms. FA is an extremely reactive compound capable of protein crosslinking and DNA damage. For a long time, FA was considered a “biochemical waste” and a by-product of normal cellular metabolism, but in recent decades the picture has changed. As a result, the need arose for novel instruments and approaches to monitor and measure not only environmental FA in water, cosmetics, and household products, but also in food, beverages and biological samples including cells and even organisms. Despite numerous protocols being developed for in vitro and in cellulo FA assessment, many of them have remained at the “proof-of-concept” stage. We analyze the suitability of different methods developed for non-biological objects, and present an overview of the recently developed approaches, including chemically-synthesized probes and genetically encoded FA-sensors for in cellulo and in vivo FA monitoring. We also discuss the prospects of classical methods such as chromatography and spectrophotometry, and how they have been adapted in response to the demand for precise, selective and highly sensitive evaluation of FA concentration fluctuations in biological samples. The main objectives of this review is to summarize data on the main approaches for FA content measurement in liquid biological samples, pointing out the advantages and disadvantages of each method; to report the progress in development of novel molecules suitable for application in living systems; and, finally, to discuss genetically encoded FA-sensors based on existing natural biological FA-responsive elements.

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Characterization of an easy-to-use method for the routine analysis of the central metabolism using an affordable low-resolution GC–MS system: application to Arthrospira platensis

et al. 2017

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We developed an easy-to-use method for the routine analysis of the central metabolism using an affordable low-resolution GC-MS system run in SIM mode. The profiling approach was optimized for the derivatization protocol of some 60 targeted metabolites. The performance of two silylation reagents (MSTFA and BSTFA) that allowed the comprehensive derivatization of 42 key intermediary metabolites of the 60 initially targeted (organic acids, phosphate derivatives, monosaccharides and amino acids) was measured. The experimental results unequivocally showed that the MSTFA reagent met mandatory criteria including ease of handling (a very simple one-step protocol was developed), comprehensiveness of derivatization (the 42 compounds covered the extended metabolic pathways of the central carbon metabolism, with a coverage percentage ranging from 17% for the worst to 90% for the best result), optimized response coefficient of the whole derivatives (median value greater than the others by one order of magnitude) and repeatability of the protocol (RSD value below 25% for the whole procedure). When tested in real conditions (cyanobacteria polar extract), the experimental results showed that the profiling methodology was adequately repeatable (RSD = 35%) to ensure quantification results comparable with much more sensitive analytical techniques (capillary electrophoresis/mass spectrometry and liquid chromatography/triple quadrupole mass spectrometry system), while needing only about twice the quantity of biomass. Graphical abstract Schematic overview of an easy-to-use profiling method for the routine analysis of the central metabolism using a low-resolution GC-MS system.

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Quality control of sweet medicines based on gas chromatography-mass spectrometry

Cited by 16 publications

References 117 publications

A pharmacognostic approach, including phytochemical and GC-MS analysis, targeted towards the authentication of Strobilanthes jomyi P. Biju, Josekutty, Rekha & J.R.I.Wood

A pharmacognostic approach, including phytochemical and GC-MS analysis, targeted towards the authentication of Strobilanthes jomyi P. Biju, Josekutty, Rekha & J.R.I.Wood

Approaches to Formaldehyde Measurement: From Liquid Biological Samples to Cells and Organisms

Characterization of an easy-to-use method for the routine analysis of the central metabolism using an affordable low-resolution GC–MS system: application to Arthrospira platensis

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