Quality control of medicinal herbs Fructus gardeniae, Common Andrographis Herb and their preparations for their active constituents by high-performance liquid chromatography–photodiode array detection–electrospray mass spectrometry

A strategy for detecting optimal ratio of cardioprotection-dependent three compounds as quality control of Guan-Xin-Er-Hao formula

“…So, it is definitely necessary because patients often decoct formula for themselves only according to the simple description such as decoction time for 0.5 h with water of 2-3 cm higher than surface of herbs in casserole twice (Takiyoshi et al, 2009). These prepared conditions often result in significant fluctuations of multi-compound contents, suggesting the irreproducible effects (Drasar and Moravcova, 2004;Mao et al, 2007;Ding et al, 2008;Wang et al, 2009). In addition, the contents of F and A in GXEH or its commercial granule were the far lower than that in the present extract although tanshinol content was the higher as indicated in Table 2.…”

“…To date, these are unclear . Influence factors contain herbal growing area, extraction solvent volume and extraction time, resulting in the fluctuation of the compound content, and the irreproducible effect (Drasar and Moravcova, 2004;Mao et al, 2007;Ding et al, 2008;Wang et al, 2009).…”

Identification of potassium dehydroandrographolidi succinas and its major metabolites in rat urine by liquid chromatography–tandem mass spectrometry

“…Thus, the molecular ion at m/z 351 was the product of adding of water across a double bond in M2. M3 or M4 can be identified as andrographolide [18]. In addition, one of the hydroxylations to yield M3 or M4 probably occurred on the methylene group on the cyclohexane ring of M2.…”

“…Thus, the molecular ion at m/z 333 was the product of the loss of one 4-oxobut-4-enoic acid from M1. M2 can be identified as dehydrographolide [18].…”

Determination of Metabolites fromScutellaria baicalensisby GC/MS and1H NMR

“…Botanicals and medicinal plants in their natural and processed products are usually used in traditional medicinal systems. Hence, the safety, efficacy, and quality of herbal medicines have steadily become an important concern for both the health authorities and the public (Ding et al 2008;Cui et al 2009;Kuo et al 2010).…”