Quality Control Method for Herbal Medicine - Chemical Fingerprint Analysis

Zhang, Yongyu; Sun, Shujun; Dai, Jianye; Wang, Wenyu; HuiJuan, Cao; Wu, Jianbing; Gou, Xiao-Jun

doi:10.5772/23962

Cited by 14 publications

(10 citation statements)

References 63 publications

(39 reference statements)

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“…Toward this aim, we believe that the pattern-oriented approach (fingerprint analysis) is a good strategy, because it can evaluate the integrative and holistic properties of test herbal medicines by comparing the similarities, differences, and correlation of the results from analyses of the whole production process, including manufacture, processing and storage of raw materials for preparation, intermediate products, finished products, and the distribution products [132, 133]. Yongyu and colleagues [134] have systematically reviewed fingerprint methods for analyses of herbal medicines. The fingerprint profiling of therapeutically used herbal medicines can be employed as a reference or index for quality control of phytochemical composition, and the results can be used in future clinical applications.…”

Section: Use Of Herbal Supplements As Adjuvants In Conventional Anmentioning

confidence: 99%

Therapeutic Applications of Herbal Medicines for Cancer Patients

Yin

Wei

Jian

et al. 2013

Evidence-Based Complementary and Alternative Medicine

254

170

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Medicinal herbs and their derivative phytocompounds are being increasingly recognized as useful complementary treatments for cancer. A large volume of clinical studies have reported the beneficial effects of herbal medicines on the survival, immune modulation, and quality of life (QOL) of cancer patients, when these herbal medicines are used in combination with conventional therapeutics. Here, we briefly review some examples of clinical studies that investigated the use of herbal medicines for various cancers and the development of randomized controlled trials (RCTs) in this emerging research area. In addition, we also report recent studies on the biochemical and cellular mechanisms of herbal medicines in specific tumor microenvironments and the potential application of specific phytochemicals in cell-based cancer vaccine systems. This review should provide useful technological support for evidence-based application of herbal medicines in cancer therapy.

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Section: Use Of Herbal Supplements As Adjuvants In Conventional Anmentioning

confidence: 99%

Therapeutic Applications of Herbal Medicines for Cancer Patients

Yin

Wei

Jian

et al. 2013

Evidence-Based Complementary and Alternative Medicine

254

170

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“…In this case, HPLC fingerprints of key components provide a new approach for quality control of traditional Chinese medicines. There are many studies about fingerprints analysis combined with chemometrics for the quality control of traditional Chinese medicines and to find the bioactive components [23,24,25,26,27].…”

Section: Introductionmentioning

confidence: 99%

Screening and Analysis of the Potential Bioactive Components of Poria cocos (Schw.) Wolf by HPLC and HPLC-MSn with the Aid of Chemometrics

Wang

Mao

et al. 2016

Molecules

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Abstract:The aim of the present study was to establish a new method based on Similarity Analysis (SA), Cluster Analysis (CA) and Principal Component Analysis (PCA) to determine the quality of different samples of Poria cocos (Schw.) Wolf obtained from Yunnan, Hubei, Guizhou, Fujian, Henan, Guangxi, Anhui and Sichuan in China. For this purpose 15 samples from the different habitats were analyzed by HPLC-PAD and HPLC-MS n . Twenty-three compounds were detected by HPLC-MS n , of which twenty compounds were tentatively identified by comparing their retention times and mass spectrometry data with that of reference compounds and reviewing the literature. The characteristic fragmentations were summarized. 3-epi-Dehydrotumulosic acid (F13), 3-oxo-16α,25-dihydroxylanosta-7,9(11),24(31)-trien-21-oic acid (F4), 3-oxo-6,16α-dihydroxylanosta-7,9(11), 24(31)-trien-21-oic acid (F7) and dehydropachymic acid (F15) were deemed to be suitable marker compounds to distinguish between samples of different quality according to CA and PCA. This study provides helpful chemical information for further anti-tumor activity and active mechanism research on P. cocos. The results proved that fingerprint combined with a chemometric approach is a simple, rapid and effective method for the quality discrimination of P. cocos.

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“…Estimation of ash values (total ash, sulphated ash, water soluble ash, acid insoluble ash) should be done by performing thermo-gravimetric analysis, differential thermal analysis and differential scanning calorimetry. 219 , 220 , 221 Moisture content must be determined precisely to assess the actual weight of the drug. Low moisture content increases the stability of the drug.…”

Section: Surmounting the Challenges Faced By Botanicalsmentioning

confidence: 99%

Integration of botanicals in contemporary medicine: road blocks, checkpoints and go-ahead signals

Chugh

Bali

Koul

2018

Integrative Medicine Research

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The use of botanicals for maintaining good health and preventing diseases is undisputed. The claimed health benefits of natural health products and herbal medicines are based on traditional claims, positive results obtained in preclinical studies and early phase clinical trials that are not backed by safety and efficacy evidences approved by regulatory agencies. Although, the popularity of botanicals is growing, health care practitioners of modern medicine seldom recommend their use because of ill equipped database of their safety and potency. This review discusses problems that preclude botanicals from integrating into the mainstream contemporary therapeutics and cues that provide impetus for their realisation.

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Quality Control Method for Herbal Medicine - Chemical Fingerprint Analysis

Cited by 14 publications

References 63 publications

Therapeutic Applications of Herbal Medicines for Cancer Patients

Therapeutic Applications of Herbal Medicines for Cancer Patients

Screening and Analysis of the Potential Bioactive Components of Poria cocos (Schw.) Wolf by HPLC and HPLC-MSn with the Aid of Chemometrics

Integration of botanicals in contemporary medicine: road blocks, checkpoints and go-ahead signals

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