Quality control evaluation of Keshamasi, Keshanjana and Keshamasi eye ointment

Abstract

Background:Keshanjana (collyrium) is a well known Ayurvedic preparation prepared out of Keshamasi (ash prepared by scalp hairs) mixed with Goghrita (cow's ghee). This medicine is indicated for the treatment of Shushkakshipaka (dry eye syndrome) in the classical literature of Ayurveda; hence, it was under taken for standardization and clinical evaluation in an extra-mural research project from Central Council for Research in Ayurvedic Sciences, Department of AYUSH, New Delhi.Aim:To develop standard quality parameters for the Keshamasi, Keshanjana and Keshamasi ointment.Materials and Methods:Scalp hairs of male and females collected from saloons were converted to classical Masi Kalpana and mixed with cow ghee and petrolatum in the ratio of 1:5 to prepare the Keshanjana and Keshamasi ointment respectively. Standard Operation Procedure (SOP) were adopted and recorded accordingly. The raw material, furnished products and plain Goghrita were subjected for quality control parameters i.e., physico-chemical evaluation, anti-microbial study, particle size analysis, heavy metal analysis through inductive couple plasma spectroscopy with high performance thin layer liquid chromatography fingerprints.Results:Rancidity was negative in all the samples, indicating that the physico-chemical parameters are in acceptable range. Lead and zinc were present in most of the samples; while all samples are were free from microbial contamination.Conclusion:As no standards are available to compare the results of the current study, the observations cannot be compared. Thus the profile generated in the current study can be considered as standard to refer in future studies.

An Emerging Approach for Optimization of Cow Ghee as an Ointment Base in Combination With Selected Conventional Bases

“…The parameters include solubility, pH, loss on drying, ash content, refractive index, specific gravity, saponification value, acid value, iodine value, moisture content, and peroxide value, which was performed for cow ghee [ 8 ]. After that total of nine ointment base formulation was prepared [ 9 ].…”

A review through therapeutic attributes of Ayurvedic formulation mashi

“…The knowledge about its chemical constituents is yet to be obtained. It is used to treat hiccups, asthma, and morning sickness during pregnancy [ 29 , 30 ].…”