Mashi is a black colored powder formulation obtained after combustion of the plant or animal drug. It is prepared by bahirdhum padhati (outside) or anterdhum padhati (in the close vessel). In this dosage form, bulk of raw material is reduced to a greater extent by the application of a certain quantum of energy. Due to this treatment, hidden chemical constituents become prominent and/or a new chemical moiety is formed which is therapeutically active. This formulation is cost-effective and easy to prepare. This review article aims to highlight the different mashi formulations mentioned in Ayurvedic text and also incorporate the formulation not mentioned in the Ayurvedic text but used by Ayurvedic practitioners. The objective was to introduce researchers to the simple yet excellent formulation mashi which should be studied in detail to establish its identity, purity, and therapeutic activity.
Aims: This study aimed to formulate and evaluate Kukkutandatvak (Hen Eggshell) bhasma tablet intended for optimum disintegration and release in the gastrointestinal tract. Methods and Material: Calcium content in Kukkutandatvak bhasma was determined using the titrimetric method. 9 formulations (F1 to F9) were prepared with Polyvinylpyrrolidone and SGS as super disintegrants. The granules were then evaluated for angle of repose, bulk density, tapped density, Hausner's ratio and Carr's index. The granules were then converted into caplet shaped tablets and were evaluated for uniformity of weight, drug content, friability, Hardness, Disintegration (in a sec) and % drug release. Results and Discussions: Calcium content in Kukkutandatvak bhasma was found to be 98%. The granules were found to be free-flowing and compressible. The Kukkutandatvak bhasma tablet had good strength and lower disintegration time (less than 135 sec), indicating a better balance between the binding and disintegration properties. The antacid activity of the tablet was evaluated by preliminary antacid test, i.e. acid-neutralizing capacity test and Rosset-Rice test. Conclusions: It was observed that Kukkutandatvak bhasma tablet (500 mg) prepared by both methods comply with Preliminary Antacid Test U.S.P. The tablet prepared neutralized 15.15 mEq of respectively in just 9.25min.
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