Qualitative detection of placidyl (ethchlorvynol) alone or in combination with poly-drugs in drug abuse urine screening programs using ion-exchange paper and/or liquid-liquid extraction

Kaistha, K.K.; Tadrus, Rahmeh

doi:10.1016/s0021-9673(01)85238-9

Cited by 2 publications

(3 citation statements)

References 9 publications

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“…These include colorimetric procedures (7)(8)(9)(10)(11)18), UV spectrophotometry(l2-14), gas liquid chromatography utilizing flame ionization(l5-20) and electron capture(21) detectors, and high pressure liquid chromatography (22). However, none of these procedures offer a quick and simple test for use in general screening of blood.…”

Section: Discussionmentioning

confidence: 99%

“…The reaction of ethchlorvynol with diphenylamine in the presence of sulphuric acid to produce a red chromophore is the basis of several colorimetric tests as well as a simple spot test for urine samples (4,(7)(8)(9)(10)(11). The procedure is sensitive and fairly specific (4,(7)(8)(9)(10)(11). The intensity of the colour, from pink to rose-red, is proportional to the ethchlorvynol concentration (7)(8)(9).…”

Section: Discussionmentioning

confidence: 99%

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A Rapid Color Test for Detection of Ethchlorvynol (Placidyl^R) in whole Hemolyzed Blood

Caughlin

1991

Canadian Society of Forensic Science Journal

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A simple, rapid, inexpensive, and reliable method to presumptively screen for the presence of ethchlorvynol is proposed. The color test is based on the reaction of ethchlorvynol and diphenylamine in the presence of acid. The method is sensitive to low therapeutic concentrations in blood. Only 200 I-tL of a methanolic extract of blood, serum or plasma is required. The test can be performed semi-quantitatively and completed within 15 minutes. RESUME Une methode simple, raplde, peu coOteuse et fiable pour le criblage initial de I'ethchlorvynol est presentee. L'essai colorimetrique est basee sur la reaction de I'ethclorvynol et de la diphenhydramine en presence d'acide. Cette rnethode peut detecter des concentrations sanguines d'ethchlorvynol qui se situent dans la partie inferieure de l'ecart therapeutique. L'essai ne requiert qu'un volume de 200 I-tL d'extrait methanolique de sang, serum ou plasma. Une analyse semi-quantitative peut etre completee en dec;a de 15 minutes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Rapid Color Test for Detection of Ethchlorvynol (Placidyl^R) in whole Hemolyzed Blood

Caughlin

1991

Canadian Society of Forensic Science Journal

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“…E-mail: mashhadizadeh@tmu.ac.ir selective electrode [8]. Sample preparation techniques prior to instrumental analysis were based on liquid-liquid extraction (LLE) [9] and solid phase extraction (SPE) [10][11][12][13]. Unfortunately, these methods require a large sample volume and are time consuming.…”

Section: Introductionmentioning

confidence: 99%

Cloud point extraction and spectrophotometric determination of codeine in pharmaceutical and biological samples

Mashhadizadeh¹,

Jafari²

2010

JICS

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Cloud point extraction process using non-ionic surfactant, Triton X-114, to extract codeine from aqueous solution was investigated. The method was based on the extraction of codeine and bromothymol blue from acetate buffer media to surfactantrich phase and formed a charge transfer-ion pair complex. The extracted surfactant-rich phase was diluted with ethanol and its absorbance was measured at 430 nm. The effect of different variables such as pH, Triton X-114 concentration, cloud point temperature and time was established. The calibration graph was linear in a wide range of 100 -700 ng ml -1 of codeine with r = 0.998 (n = 7). The detection limit based on three times standard deviation of the blank (3s) was 4.6 ng ml -1 and relative standard deviation (R.S.D) is 2.15% for 500 ng ml -1 codeine (n = 5). The proposed method was applied to the determination of codeine in acetaminophen codeine tablets and blood samples.

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Qualitative detection of placidyl (ethchlorvynol) alone or in combination with poly-drugs in drug abuse urine screening programs using ion-exchange paper and/or liquid-liquid extraction

Cited by 2 publications

References 9 publications

A Rapid Color Test for Detection of Ethchlorvynol (Placidyl^R) in whole Hemolyzed Blood

A Rapid Color Test for Detection of Ethchlorvynol (Placidyl^R) in whole Hemolyzed Blood

Cloud point extraction and spectrophotometric determination of codeine in pharmaceutical and biological samples

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Qualitative detection of placidyl (ethchlorvynol) alone or in combination with poly-drugs in drug abuse urine screening programs using ion-exchange paper and/or liquid-liquid extraction

Cited by 2 publications

References 9 publications

A Rapid Color Test for Detection of Ethchlorvynol (PlacidylR) in whole Hemolyzed Blood

A Rapid Color Test for Detection of Ethchlorvynol (PlacidylR) in whole Hemolyzed Blood

Cloud point extraction and spectrophotometric determination of codeine in pharmaceutical and biological samples

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Product

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A Rapid Color Test for Detection of Ethchlorvynol (Placidyl^R) in whole Hemolyzed Blood

A Rapid Color Test for Detection of Ethchlorvynol (Placidyl^R) in whole Hemolyzed Blood