Qualitative Analysis of Halothane Metabolites in Man

Halothane Hepatitis as Seen by the Physician

“…However, some 20 per cent of absorbed halothane is metabolized in the hepatic microsomal enzymes. In man, the chief metabolite is trifluoro- acetate (Blake, Barry and Cascorbi, 1972), which is chemically reactive, and quite capable of binding to tissue proteins to form an immunologically active protein-hapten complex (Cohen, 1971). Subsequent exposure to circulating lymphocytes could initiate an immune response.…”

Identification and characterization of conservative organic tracers for use as hydrologic tracers for the Yucca Mountain site characterization study. Final report

“…Studies of exposure to halothane anesthetics in humans has shown TFAA to be the major metabolic product (Rehder, 1967;Blake, 1972;Cohen, 1975;Witte, 1977). The fact that operating room personnel are continuously exposed to low level concentrations of halothane anesthetics, coupled with the much higher doses received by patients undergoing anesthesia, suggest that the halothane anesthetics are relatively safe at the dosages applied.…”

Identification and characterization of conservative organic tracers for use as hydrologic tracers for the Yucca Mountain Site characterization study; Progress report, April 1, 1993--June 30, 1993

“…Studies of exposure to halothane anesthetics in humans has shown TFAA to be the major metabolic product (Rehder, 1967;Blake, 1972;Cohen, 1975;Witte, 1977). The fact that operating room personnel are continuously exposed to low level concentrations of halothane anesthetics, coupled with the much higher doses received by patients undergoing anesthesia, suggest that the halothane anesthetics are relatively safe at the dosages applied.…”