Halothane Hepatitis as Seen by the Physician

Reed, W. D.; Williams, Roger

doi:10.1093/bja/44.9.935

Cited by 12 publications

(1 citation statement)

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“…Several reviews have appeared which by their title suggest a relationship between anaesthesia and liver function (Dykes, 1970;Editorial, 1972). There is evidence connecting liver dysfunction with halothane (Sherlock, 1971;Reed and Williams, 1972) and particularly with a second administration a few weeks after the first (Mushin, Rosen and Jones, 1971;Inman and Mushin, 1974;Wright et al, 1975). On the other hand, there have been many studies which do not support this connection, or which suggest the alternative possibility of viral hepatitis as a possible cause (National Halothane Study, 1966;Walton et al, 1972;Simpson, Strunin and Walton, 1973).…”

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confidence: 99%

Changes in Liver Function After Different Types of Surgery

Clarke¹,

Doggart

Lavery

1976

British Journal of Anaesthesia

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Liver function tests carried out after minor surgical procedures, under anaesthesia lasting for 1 hr, showed no abnormalities. Tests after body surface operations under the same anaesthetic techniques showed transient derangements. After intra-abdominal procedures, liver dysfunction was more marked, although no patients with evidence of preoperative liver dysfunction or postoperative surgical complications were studied and none received blood transfusions. Measurements of the serum bilirubin concentration showed the most frequent abnormalities, but the pseudocholinesterase concentration decreased progressively after intra-abdominal surgery and b.s.p. retention increased significantly. Serum concentration of intracellular enzymes (LDH, s.g.o.t. and s.g.p.t.) increased within an hour of starting surgery, changes which were probably not related to liver function.

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confidence: 99%