Quadruple advanced synchronous colorectal cancers successfully treated by laparoscopic surgery: a case report

Ma, Jianwei; Akagi, Tomonori; Etoh, Tsuyoshi; Kono, Yohei; Suzuki, Kosuke; Ninomiya, Shigeo; Shibata, Tomotaka; Ueda, Y.; Toujigamori, Manabu; Shiroshita, Hidefumi; Shiraishi, Norio; Ito, Masafumi

doi:10.1093/jscr/rjaa256

Cited by 2 publications

(2 citation statements)

References 10 publications

(11 reference statements)

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“…Meanwhile, adenocarcinomas are more commonly seen in SCRC patients. As reported in other cases with triple [ 7 , 8 ] or quadruple [ 9 ] SCRC, the adenocarcinomas were frequently identified in the sigmoid colon, ascending and descending colon respectively. The presence of various histology types in the same patient indicated that carcinogenesis underlying multiple tumor lesions of SCRC might be different.…”

Section: Discussionsupporting

confidence: 76%

Genomic profiling of a patient with quadruple synchronous colorectal cancer: a case report

et al. 2021

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Background Synchronous colorectal cancer (SCRC) is featured by the presence of multiple primary tumor lesions in a single patient at initial diagnosis. It is less common with the prevalence of approximately 3.5% among colorectal cancer (CRC). Some studies of SCRC have been performed in patients with two tumor lesions. However, SCRC cases with three or more tumor lesions were rare and remained to be investigated. Case presentation In this case report, we presented a 56-year-old male SCRC case with quadruple tumor lesions which is rarely seen in clinical practice. After laparoscopic radical resection of sigmoid carcinoma and partial rectum resection, the four tumor samples were subjected to pathological evaluation and next-generation sequencing (NGS) based genetic profiling. The four tumor lesions included two adenocarcinomas with moderate differentiation at sigmoid colon and rectum respectively, a grade 1 neuroendocrine tumor (NET) at rectum and a high-grade intraepithelial neoplasia at ascending colon. Each tumor exhibited distinct histology types and mutation profiles. After surgical resection, the patient remained disease-free after four cycles of chemotherapy with oxaliplatin and capecitabine (XELOX). Conclusions The tumor lesions in this case showed different pathological and genetic features which indicats the heterogeneity of SCRC. The genomic profilling might provide novel insights to understand SCRC at molecular level.

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Section: Discussionsupporting

confidence: 76%

Genomic profiling of a patient with quadruple synchronous colorectal cancer: a case report

et al. 2021

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“…Synchronous colorectal cancers (SCRCs) are characterized by the simultaneous occurrence of multiple primary tumours in the same patient [1]. Synchronous malignancies most commonly occur in the colon among other organs [2][3][4].…”

Section: Laparoscopic Subtotal Colectomy With Complete Mesocolic Exci...mentioning

confidence: 99%

Laparoscopic subtotal colectomy with complete mesocolic excision, central vascular ligation – A video vignette

Dasgupta

Pai

2021

Colorectal Disease

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Quadruple advanced synchronous colorectal cancers successfully treated by laparoscopic surgery: a case report

Cited by 2 publications

References 10 publications

Genomic profiling of a patient with quadruple synchronous colorectal cancer: a case report

Genomic profiling of a patient with quadruple synchronous colorectal cancer: a case report

Laparoscopic subtotal colectomy with complete mesocolic excision, central vascular ligation – A video vignette

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