QT Dispersion as an Attribute of T-Loop Morphology

Kors, Jan A.; Herpen, Gerard van; Bemmel, Jan H. van

doi:10.1161/01.cir.99.11.1458

Cited by 196 publications

(128 citation statements)

References 33 publications

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“…Indeed, several reports show that in patients with acute myocardial infarction or Behçet's disease, QT dispersion is associated with LV dilation and deterioration of diastolic function (20,25,28). However, Kors et al suggested an important point that at all electrode sites, repolarization potentials must have principally the same duration by simple electric field theory (29). Other studies also suggested that QT dispersion is an attribute of T-loop morphology or projection effect (30,31).…”

Section: Discussionmentioning

confidence: 99%

QT Dispersion Correlates with Systolic Rather than Diastolic Parameters in Patients Receiving Anthracycline Treatment

et al. 2004

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Objective The aim of this study was to investigate the relation of QT dispersion to left ventricular (LV) systolic and diastolic function in patients undergoing anthracycline therapy.Methods We used echocardiography to evaluate LV systolic and diastolic function and electrocardiography to evaluate QT dispersion and corrected QT dispersion (QTcD) in patients with hematological diseases, who received anthracycline therapy.Patients Seventy-two patients with hematological diseases who were receiving anthracycline treatment were enrolled in the present study.Results LV end-diastolic diameter or LV end-systolic diameter had a significant positive correlation to QTcD

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Section: Discussionmentioning

confidence: 99%

QT Dispersion Correlates with Systolic Rather than Diastolic Parameters in Patients Receiving Anthracycline Treatment

et al. 2004

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“…40 QT interval dispersion is no longer believed to represent spatial inhomogeneity of repolarization throughout the ventricular myocardium, 13 as originally proposed. 1 Several recent studies 41,42 have demonstrated that it probably indicates a global ventricular repolarization abnormality, reflected by an altered, more complex, spatial vectorcardiographic T-wave loop, as would be expected to occur in the hypertrophied myocardium with increased interstitial fibrosis. This is the most probable explanation, we think, for the observed association between LVM and QT interval dispersion.…”

Section: Discussionmentioning

confidence: 99%

Multivariate associates of QT interval parameters in diabetic patients with arterial hypertension: importance of left ventricular mass and geometric patterns

2003

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The aim of the study was to assess the determinants of increased QT interval parameters in diabetic patients with arterial hypertension and, in particular, the strength of their relationships to echocardiographically derived left ventricular mass (LVM) and geometric patterns. In a cross-sectional study with 289 hypertensive type 2 diabetic outpatients, maximal QT and QT c (heart ratecorrected) intervals, and QT, QT c , and number-of-leadsadjusted QT interval dispersions were manually measured from standard baseline 12-lead ECGs. Electrocardiographic criteria for left ventricular hypertrophy (LVH) were either Sokolow-Lyon or Cornell sex-specific voltages. LVM and geometric patterns were determined by 2D echocardiography. Statistical analyses involved bivariate tests (Mann-Whitney, v 2 , Spearman's correlation coefficients, ANOVA and receiver-operating-characteristic (ROC) curve analyses) and multivariate tests (multiple linear and logistic regressions). QT dispersion measurements showed significant correlations with echocardiographic LVM (r ¼ 0.26-0.27). ROC curves demonstrated a poor isolated predictive performance of all QT parameters for detection of LVH (areas under curve: 0.58-0.59), comparable to that of electrocardiographic voltage criteria. Only patients with concentric hypertrophy had significantly increased QT dispersion (QT d ) when compared to those with normal geometries (64.24 7 21.09 vs 53.20 7 15.35, Po0.05). In multivariate analyses, both electrocardiographic and echocardiographic LVH were independent predictors of increased QT d , as well as only QT d and gender were determinants of LVM. In conclusion, increased QT interval dispersion is associated with LVM and concentric hypertrophy geometric pattern in diabetic hypertensive patients, although in isolation neither QT d nor any QT parameter presents enough predictive performance to be recommended as screening procedures for detection of LVH.

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“…32 This only adds further to the growing impression that even though QT dispersion to a certain point does reflect ventricular repolarization, future effort should be made to express repolarization abnormalities in other and more reproducible manners, also with regard to survival analysis.…”

Section: Discussionmentioning

confidence: 99%

The prognostic value of QTC interval and QT dispersion following myocardial infarction in patients treated with or without dofetilide

Brendorp

Elming

et al. 2003

Clinical Cardiology

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SummaryBackground: Acute myocardial infarction (MI) is associated with an increased risk of death, with a 1-year mortality close to 10% in patients discharged from hospital alive. During the first year following MI, close to 50% of deaths are assumed to be due to arrhythmic events.Hypothesis: The study was undertaken to determine the interaction between dofetilide treatment and pretreatment QTc interval and QT dispersion regarding mortality in patients with left ventricular (LV) dysfunction and a recent MI.Methods: The study population consisted of 894 patients with a recent MI and LV systolic dysfunction, who were randomized to receive dofetilide or placebo. The study was a substudy of the Danish Investigations of Arrhythmia and Mortality on Dofetilide-MI (DIAMOND-MI).Results: During a minimum of 1-year follow-up, 261 (29%) patients died. Baseline QTc interval did not hold any prognostic value on mortality for placebo-treated patients. When pretreatment QTc interval was < 429 ms, dofetilide resulted in a 45% reduction of mortality (hazard ratio 0.55, 95% confidence limits 0.34-0.88, p < 0.02) compared with placebo. When QTc interval was > 429 ms, dofetilide did not influence mortality significantly. This study revealed no statistically significant relation between QT dispersion, dofetilide treatment, and mortality.

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QT Dispersion as an Attribute of T-Loop Morphology

Abstract: QTD is an attribute of T-loop morphology, as expressed by T-loop amplitude and width.

Cited by 196 publications

References 33 publications

QT Dispersion Correlates with Systolic Rather than Diastolic Parameters in Patients Receiving Anthracycline Treatment

QT Dispersion Correlates with Systolic Rather than Diastolic Parameters in Patients Receiving Anthracycline Treatment

Multivariate associates of QT interval parameters in diabetic patients with arterial hypertension: importance of left ventricular mass and geometric patterns

The prognostic value of QTC interval and QT dispersion following myocardial infarction in patients treated with or without dofetilide

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