QT Dispersion Correlates with Systolic Rather than Diastolic Parameters in Patients Receiving Anthracycline Treatment

Abstract

Objective The aim of this study was to investigate the relation of QT dispersion to left ventricular (LV) systolic and diastolic function in patients undergoing anthracycline therapy.Methods We used echocardiography to evaluate LV systolic and diastolic function and electrocardiography to evaluate QT dispersion and corrected QT dispersion (QTcD) in patients with hematological diseases, who received anthracycline therapy.Patients Seventy-two patients with hematological diseases who were receiving anthracycline treatment were enrolled in the present study.Results LV end-diastolic diameter or LV end-systolic diameter had a significant positive correlation to QTcD

Increased QT Dispersion in Sickle Cell Disease: Effect of Pulmonary Hypertension

“…Previous studies have shown that QT dispersion was associated with LV dilation [22]. As our patients with SCD had an increased ventricular diameter compared with healthy controls, the increase in QT dispersion in our patients may be partially due to ventricular dilation.…”

Long-term Cardiovascular Toxicity in Children, Adolescents, and Young Adults Who Receive Cancer Therapy: Pathophysiology, Course, Monitoring, Management, Prevention, and Research Directions

“…The relationship between myocyte dysfunction and arrhythmogenesis in cancer cardiotoxicity is not completely determined; however, an investigation by Nakamae et al 61 of 72 adults receiving anthracycline therapy suggests a link between these problems. In that study, the QTc interval during anthracycline therapy correlated moderately well with the degree of LV enlargement (r=0.…”

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