QT dispersion and mortality after myocardial infarction

Glancy, James; Garratt, Clifford J.; Bono, David P. de; Woods, K L

doi:10.1016/s0140-6736(95)90697-5

Cited by 302 publications

(151 citation statements)

References 20 publications

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“…In this way, QTc dispersion proved to be an independent predictor of cardiac and cerebrovascular mortality [35][36][37] . On the other hand, a smaller QTc dispersion is associated with a smaller mortality rate after acute myocardial infarction 38 , in addition to improving prognosis in individuals with congestive heart failure 39 . In our study, administration of pyridostigmine bromide increased the duration of the RR interval and decreased QTc dispersion without altering the other electrocardiographic variables studied.…”

Section: Discussionmentioning

confidence: 99%

Reduction of QTc interval dispersion. Potential mechanism of cardiac protection of pyridostigmine bromide

Castro

Serra

Nóbrega

2000

Arq. Bras. Cardiol.

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Section: Discussionmentioning

confidence: 99%

Reduction of QTc interval dispersion. Potential mechanism of cardiac protection of pyridostigmine bromide

Castro

Serra

Nóbrega

2000

Arq. Bras. Cardiol.

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“…In normal subjects, prolongation of the QT interval is associated with an excess mortality risk [4,5], and in patients with coronary artery disease, heart failure and peripheral vascular disease, QT interval prolongation increases the risk of developing ventricular tachyarrhythmias and sudden cardiac death [6,7,8]. Abnormal ventricular repolarisation with prolongation of the QT interval during episodes of nocturnal hypoglycaemia therefore offers a mechanism by which hypoglycaemia could induce ventricular tachyarrhythmias and thus contribute to the increased mortality rates in young patients with type 1 diabetes [8].…”

Section: Introductionmentioning

confidence: 99%

Prolonged cardiac repolarisation during spontaneous nocturnal hypoglycaemia in children and adolescents with type 1 diabetes

et al. 2004

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Aims/hypothesis. It has been postulated that hypoglycaemia-related cardiac dysrhythmia and, in particular, prolonged cardiac repolarisation, may contribute to increased mortality rates in children and adolescents with type 1 diabetes. Methods. We examined the prevalence of prolonged QT interval on ECG during spontaneous hypoglycaemia in 44 type 1 diabetic subjects (aged 7-18 years), and explored the relationships between serial overnight measurements of QT interval corrected for heart rate (QTc) and serum glucose, potassium and epinephrine levels. Each subject underwent two overnight profiles; blood was sampled every 15 min for glucose measurements and hourly for potassium and epinephrine. Serial ECGs recorded half-hourly between 23.00 and 07.00 hours were available on 74 nights: 29 with spontaneous hypoglycaemia (defined as blood glucose <3.5 mmol/l) and 45 without hypoglycaemia.Results. Mean overnight QTc was longer in females than in males (412 vs 400 ms, p=0.02), but was not related to age, diabetes duration or HbA 1 c. Prolonged QTc (>440 ms) occurred on 20 out of 74 (27%) nights, with no significant differences between male and female subjects, and was more prevalent on nights with hypoglycaemia (13/29, 44%) than on nights without (7/45, 15%, p=0.0008). Potassium levels were lower on nights when hypoglycaemia occurred (minimum potassium 3.4 vs 3.7 mmol/l, p=0.0003) and were inversely correlated with maximum QTc (r=−0.40, p=0.03). In contrast, epinephrine levels were not higher on nights with hypoglycaemia and were not related to QTc. Conclusions/interpretation. In young type 1 diabetic subjects, prolonged QTc occurred frequently with spontaneous overnight hypoglycaemia and may be related to insulin-induced hypokalaemia.

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“…QT dispersion has been widely studied as a marker for arrhythmia risk and as a prognostic factor for some heart diseases (4)(5)(6)(7)(8). While these studies show that QT dispersion has some diagnostic capability, the clinical value of QT dispersion remains controversial and unclear.…”

Section: Introductionmentioning

confidence: 99%

QT Dispersion Correlates with Systolic Rather than Diastolic Parameters in Patients Receiving Anthracycline Treatment

et al. 2004

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Objective The aim of this study was to investigate the relation of QT dispersion to left ventricular (LV) systolic and diastolic function in patients undergoing anthracycline therapy.Methods We used echocardiography to evaluate LV systolic and diastolic function and electrocardiography to evaluate QT dispersion and corrected QT dispersion (QTcD) in patients with hematological diseases, who received anthracycline therapy.Patients Seventy-two patients with hematological diseases who were receiving anthracycline treatment were enrolled in the present study.Results LV end-diastolic diameter or LV end-systolic diameter had a significant positive correlation to QTcD

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QT dispersion and mortality after myocardial infarction

Cited by 302 publications

References 20 publications

Reduction of QTc interval dispersion. Potential mechanism of cardiac protection of pyridostigmine bromide

Reduction of QTc interval dispersion. Potential mechanism of cardiac protection of pyridostigmine bromide

Prolonged cardiac repolarisation during spontaneous nocturnal hypoglycaemia in children and adolescents with type 1 diabetes

QT Dispersion Correlates with Systolic Rather than Diastolic Parameters in Patients Receiving Anthracycline Treatment

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