QSAR studies and antimicrobial potential of 1,3-thiazolylphosphonium salts

Abstract

The regression QSAR models were built to predict the antimicrobial activity of new thiazole derivatives. Compounds with high predicting activity were synthesized and evaluated against Gram-positive and Gram-negative bacteria and fungi. 1,3-Thiazole-4-ylphosphonium salts 4 and 5 displayed good antibacterial properties and high antifungal activity. The predictions are in a good agreement with the experiment results, which indicate the good predictive power of the created QSAR models.

1,3-Oxazol-4-ylphosphonium salts as new non-peptide inhibitors of furin

“…One of these groups is the lipophilic triphenyl-phosphonium (TPP) ion [30][31][32]. Indeed, the derivatives, bearing quaternary phosphonium salts were reported to show high antimicrobial activities [33][34][35] so that these cations were considered as a new generation of effective antiseptics. As pharmacological agents, TPP salts found to have also antiglycemic properties [36] and antiproliferative [36], antioxidant [37], antiviral activities [34].…”