QSAR, Docking and Invitro Antioxidant Activity Study of Novel Chromone Derivatives

Abstract

:Invitro antioxidant activity and Molecular modeling studies of nine chromone derivatives optimize their inhibitory activity against Poly [ADP correlated to different molecular properties. The AM1and PM3 semiempirical methods are used to estimate vertical ioniz tion potentials (IPv's), electron affinity (EA tion coefficient (LogP), hydration energ regression analysis are proposed. The leave final QSAR equations. The hardness (η) was found to be studies of chromone with Poly [ADP-ribose results of both QSAR and Docking studies suggested that remarkable inhibi hydrogen bond interactions along with hydrophobic and electrostatic interactions