The bispyrazolines 3a-3h built around the alkyl chains of varying lengths have been synthesized from the cyclization reactions of bischalcones with phenyl hydrazine. The bischalcones 2a-2h were obtained from the Claisen-Schmidt reactions of acetophenone with various bisaldehydes 1a-1h. The intermediate bischalcones and final bisheterocyclic compounds have been characterized by means of IR, 1 H-NMR, 13 C-NMR, Mass (ESI) and elemental analysis. The antibacterial and antifungal activities of the synthesized compounds were also evaluated against the Klubsellia pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Bacillius subtilis and Aspergillius janus, Aspergillus niger and Pencillium glabrum, respectively. The antimicrobial behaviour of the bispyrazolines 3a-3h is found to be dependent on the length of internal spacer unit.
The bisthiadiazolines 4a(a-f) and 4b(a-f) built around the various rigid chains have been synthesized in good yields by refluxing bisthiosemicarbazones 3a(a-f) and 3b(a-f) in acetic anhydride medium. The reaction of bisaldehydes 2a(a-f) and 2b(a-f) with thiosemicarbazide under alcoholic medium yielded 3a(a-f) and 3b(a-f) and the former were obtained from the reaction of 2/4-hydroxybenzaldehyde with suitable alkylating agent in the presence of anhydrous K 2 CO 3 /dry acetone and Bu 4 N + I − (PTC). The intermediates and final compounds have been characterized from the rigorous analysis of their IR, 1 H-NMR, 13 C-NMR, ESI-Mass and elemental analysis. The antibacterial and antifungal activities of the prepared compounds were also evaluated against the Klubsellia pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Bacillius subtilis and Aspergillius janus and Pencillium glabrum strains, respectively. The formation and antimicrobial behaviour of the bisthiadiazolines 4a(a-f) and 4b(a-f) are found to be independent of nature of the internal spacer unit.
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