Qing brick tea (QBT) aqueous extract protects monosodium glutamate-induced obese mice against metabolic syndrome and involves up-regulation Transcription Factor Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) antioxidant pathway

Gao, Wenqi; Changyi, Xiao; Hu, Jun; Chen, Biaoxin; Wang, Chunyan; Cui, Bangping; Deng, Pengyi; Yang, Jian; Deng, Zhifang

doi:10.1016/j.biopha.2018.04.043

Cited by 31 publications

(20 citation statements)

References 29 publications

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“…In our study, marked upregulation in the expression of hepatic and renal Nrf2 in MSGexposed group was recorded as compared with the control. These results are in agreement with Gao et al (Gao et al 2018) who reported marked decreases in both mRNA and protein expressions of Nrf2 in response to MSG exposure in mice. In all, our data showed that MSG induced oxidative damage via downregulation of Nrf2 expression level associated with attenuated antioxidant defense and elevated lipid peroxidation level in hepatic and renal tissues.…”

Section: Discussionsupporting

confidence: 93%

“…Normally, Nrf2 is inactive and combined with Kelch-like ECH-associated protein-1 (KEAP-1) in the cytoplasm but, in cases of oxidative stress status, Nrf2 translocate to the nucleus to bind ARE. Such binding elicits the downstream activation of antioxidant and detoxi cation enzymes to restore cell homeostasis status (Gao et al 2018). In our study, marked upregulation in the expression of hepatic and renal Nrf2 in MSGexposed group was recorded as compared with the control.…”

Section: Discussionsupporting

confidence: 49%

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Protocatechuic acid abrogates oxidative insults, inflammation, and apoptosis in liver and kidney associated with monosodium glutamate intoxication in rats

Kassab

Theyab

Al-Ghamdy

et al. 2021

Environ Sci Pollut Res

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Monosodium glutamate (MSG), a commonly used avor enhancer, has been reported to induce hepatic and renal dysfunctions. In this study, the palliative role of protocatechuic acid (PCA) in MSG-administered rats was elucidated. Adult male rats were assigned to four groups, namely control, MSG (4 mg/kg), PCA (100 mg/kg), and the last group was co-administered MSG and PCA at aforementioned doses for seven days. Results showed that MSG augmented the hepatic (AST and ALT) and renal (urea and creatinine) functions markers as well as glucose, triglycerides, total cholesterol and LDL levels. Moreover, marked increases in MDA levels accompanied by declines in GSH levels and notable decreases in the activities of SOD, CAT, GPx, and GR were observed in MSG-treated group. The MSG-mediated oxidative stress was further con rmed by down-regulation of Nfe2l2 gene expression levels in both tissues. In addition, MSG enhanced the hepatorenal in ammatory response as witnessed by increased in ammatory cytokines (IL-1b and TNF-α) and elevated NF-κB levels in both tissues. Further, signi cant increases in Bax (proapoptotic biomarker) levels together with decreases in Bcl-2 (anti-apoptotic marker) levels were observed in MSG administration. Hepatic and renal histopathological screening supported the biochemical and molecular ndings. On the contrary, co-treatment of rats with PCA resulted in remarkable enhancement of the antioxidant cellular capacity, suppression of in ammatory mediators and apoptosis. These effects are possibly endorsed for activation of Nrf-2 and suppression of NF-kB signaling pathways. Collectively, addition of PCA counteracted MSG-induced hepatic and renal injurious effects through modulation of oxidative, in ammatory and apoptotic alterations.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 49%

Protocatechuic acid abrogates oxidative insults, inflammation, and apoptosis in liver and kidney associated with monosodium glutamate intoxication in rats

Kassab

Theyab

Al-Ghamdy

et al. 2021

Environ Sci Pollut Res

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“…As previously described, green tea extract and green tea catechins ameliorate inflammatory responses and oxidative stress by suppressing NF-κB activation (Li et al, 2017;Marinovic et al, 2015). Additionally, GTAE stimulates the expression of Nrf2 and its target genes NQO-1 and HO-1 in the liver, indicating that GTAE protects hepatocytes against oxidative stress potentially via the NRF2 pathway (Gao et al, 2018;Sampath et al, 2017).…”

Section: Discussionmentioning

confidence: 71%

“…As previously described, green tea extract and green tea catechins ameliorate inflammatory responses and oxidative stress by suppressing NF‐κB activation (Li et al., 2017 ; Marinovic et al., 2015 ). Additionally, GTAE stimulates the expression of Nrf2 and its target genes NQO‐1 and HO‐1 in the liver, indicating that GTAE protects hepatocytes against oxidative stress potentially via the NRF2 pathway (Gao et al., 2018 ; Sampath et al., 2017 ). Since NRF2 activates fatty acid oxidation‐related genes and further improves the lipid blood profile, this may explain the mechanism through which GTAE attenuates lipid content in the liver (Vasileva et al., 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Green tea aqueous extract (GTAE) prevents high‐fat diet‐induced obesity by activating fat browning

Chen

Zhai

et al. 2021

Food Science & Nutrition

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The global prevalence of overweight and obesity has increased markedly, and obesity has become a serious health concern (Afshin et al., 2017). Moreover, obesity is a risk factor for the development of many diseases, including type-2 diabetes, nonalcoholic fatty liver disease, cardiovascular disease, and several cancer types among others (Hruby & Hu, 2015;Ren et al., 2021). Emerging evidence suggests the occurrence of pathogenic events in the development and progression of obesity-associated comorbidities, including lowgrade systemic inflammation, oxidative stress, and insulin resistance (Hernandez-Bautista et al., 2019;Romeo et al., 2012). Therefore, it is critical to investigate the physiological mechanisms during the occurrence and development of obesity.In mammals, brown adipose tissue (BAT) is metabolically highly active and dissipates energy as heat through nonshivering thermogenesis (Cannon & Nedergaard, 2004). In addition, BAT is a multilocular organ that contains a relatively large number of mitochondria that produce heat via uncoupling of the respiratory chain (Poekes et al., 2015). BAT maintains temperature in newborn infants and small mammals (McMillan & White, 2015). Recent studies have demonstrated that adults also possess metabolically active brown fat or "beige adipocyte" (browning of white adipose

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“…Among these recent studies, tea has a role in the prevention and treatment of the metabolic syndromes is noteworthy, because findings are intermingled in this perspective. Based on pooled (Hibi, Takase, Iwasaki, Osaki, & Katsuragi, 2018) and experimental analyses (Gao et al, 2018), studies suggested that tea can reduce the risk of metabolic syndromes. Several recent reviews detailed the effects and mechanisms of tea for the prevention of diabetes and cardiovascular diseases (Cao et al, 2019; Meng et al, 2019; Tang et al, 2019), although hypertension, HDL, and obesity were not discussed, and the adverse effects of tea on MetS were not mentioned.…”

Section: Introductionmentioning

confidence: 99%

Effects of tea consumption on metabolic syndrome: A systematic review and meta‐analysis of randomized clinical trials

Liu

Wan

Huang

et al. 2020

Phytotherapy Research

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The metabolic syndrome (MetS) is one of the major health hazards and an epidemic worldwide. There is no known best remedy has been defined yet. In the current investigation, we designed a meta-analysis of randomized clinical trials (RCTs) to evaluate the beneficial effects of tea consumption in alleviating metabolic syndromes. Herein, we accumulated the relevant literature available on PubMed and EMBASE databases from January, 2000 to August, 2019. RCTs bearing impact factor of at least 1 or more were studied for the effect of tea consumption on MetS. This metaanalysis suggested that tea consumption has beneficial effects on diastolic blood pressure (DBP), and this finding was characterized of all types of tea in the current study and also for body mass index (BMI) value. Furthermore, this analysis also found that black tea consumption has protective effects on systolic SBP, green tea reduces the incidence of diabetes and lower the level of low-density lipoprotein (LDL) cholesterol. These functions required BMI value at least 28 or higher. The meta data led us to conclude that tea consumption have protective effects on MetS, however, different types of tea might have different protective mechanisms on MetS, but, exact mechanisms are not yet clear and needs to be explored.

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Qing brick tea (QBT) aqueous extract protects monosodium glutamate-induced obese mice against metabolic syndrome and involves up-regulation Transcription Factor Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) antioxidant pathway

Cited by 31 publications

References 29 publications

Protocatechuic acid abrogates oxidative insults, inflammation, and apoptosis in liver and kidney associated with monosodium glutamate intoxication in rats

Protocatechuic acid abrogates oxidative insults, inflammation, and apoptosis in liver and kidney associated with monosodium glutamate intoxication in rats

Green tea aqueous extract (GTAE) prevents high‐fat diet‐induced obesity by activating fat browning

Effects of tea consumption on metabolic syndrome: A systematic review and meta‐analysis of randomized clinical trials

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