QCM Technology in Biosensors

Montagut, Y. J.; Narbon, Jose Garcia; Jiménez, Yolanda; March, Carmen; Montoya, Ángel; Arnau, Antonio

doi:10.5772/17991

Cited by 22 publications

(24 citation statements)

References 104 publications

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“…One big difference between phononic crystals and other resonant sensors, like the quartz crystal microbalance, QCM, is that PnC allows to perform an evaluation of the volumetric properties of liquid samples and not of properties of the liquid at an interface. PnC sensors combine the characteristics of resonant sensors and ultrasonic sensors by using the propagation of acoustic waves through liquids and measuring changes in the frequency response of the system to determine its properties [30,31]. This paper reports the design, manufacture, and evaluation of a fully-disposable multi-layered phononic crystal liquid sensor with symmetry reduction and a resonant cavity that can be used in applications that require the measurement of small liquid samples in the field.…”

Section: (B)mentioning

confidence: 99%

Fully-disposable multilayered phononic crystal liquid sensor with symmetry reduction and a resonant cavity

et al. 2017

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. Fullydisposable multilayered phononic crystal liquid sensor with symmetry reduction and a resonant cavity. Measurement: Journal of the International Measurement Confederation, 102, pp. 20-25. doi: 10.1016Confederation, 102, pp. 20-25. doi: 10. /j.measurement.2017 This is the accepted version of the paper.This version of the publication may differ from the final published version. Permanent b s t r a c tPhononic crystals are artificial structures with unique capabilities to control the transmission of acoustic waves. These novel periodic composite structures bring new possibilities for developing a fundamentally new sensor principle that combines features of both ultrasonic and resonant sensors. This paper reports the design, fabrication and evaluation of a phononic crystal sensor for biomedical applications, especially for its implementation in point of care testing technologies. The key feature of the sensor system is a fully-disposable multi-layered phononic crystal liquid sensor element with symmetry reduction and a resonant cavity. The phononic crystal structure consists of eleven layers with high acoustic impedance mismatch. A defect mode was utilized in order to generate a well-defined transmission peak inside the bandgap that can be used as a measure. The design of the structures has been optimized with simulations using a transmission line model. Experimental realizations were performed to evaluate the frequency response of the designed sensor using different liquid analytes. The frequency of the characteristic transmission peaks showed to be dependent on the properties of the analytes used in the experiments. Multi-layered phononic crystal sensors can be used in applications, like point of care testing, where the on-line measurement of small liquid samples is required.

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Section: (B)mentioning

confidence: 99%

Fully-disposable multilayered phononic crystal liquid sensor with symmetry reduction and a resonant cavity

et al. 2017

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“…a fluorophore). Differently, microcantilevers and QCMs are especially attractive for immunosensors because of the potential to microfabricate immunosensors at low cost: antigenantibody complex can be detected as mass change causing a vibration frequency shift, without using additional labels [226,227].…”

Section: Immunosensorsmentioning

confidence: 99%

Electrospinning for High Performance Sensors

Macagnano¹,

Zampetti²,

Kny³

2015

NanoScience and Technology

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The series NanoScience and Technology is focused on the fascinating nano-world, mesoscopic physics, analysis with atomic resolution, nano and quantum-effect devices, nanomechanics and atomic-scale processes. All the basic aspects and technology-oriented developments in this emerging discipline are covered by comprehensive and timely books. The series constitutes a survey of the relevant special topics, which are presented by leading experts in the field. These books will appeal to researchers, engineers, and advanced students.More information about this series at

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“…However, in spite of the efforts carried out to build oscillator configurations suitable for in-liquid applications [ 74 – 81 ], the poor stability of high frequency QCM systems based on oscillators has prevented the increase of resolution despite the higher sensitivity reported [ 82 – 85 ]. The main reasons are discussed elsewhere [ 52 , 86 ].…”

Section: Phase-mass Characterization Concept For In-liquid High Resolmentioning

confidence: 99%

Validation of a Phase-Mass Characterization Concept and Interface for Acoustic Biosensors

Montagut

García

Jiménez

et al. 2011

Sensors

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Acoustic wave resonator techniques are widely used in in-liquid biochemical applications. The main challenges remaining are the improvement of sensitivity and limit of detection, as well as multianalysis capabilities and reliability. The sensitivity improvement issue has been addressed by increasing the sensor frequency, using different techniques such as high fundamental frequency quartz crystal microbalances (QCMs), surface generated acoustic waves (SGAWs) and film bulk acoustic resonators (FBARs). However, this sensitivity improvement has not been completely matched in terms of limit of detection. The decrease on frequency stability due to the increase of the phase noise, particularly in oscillators, has made it impossible to increase the resolution. A new concept of sensor characterization at constant frequency has been recently proposed based on the phase/mass sensitivity equation: Δφ/Δm ≈ −1/mL, where mL is the liquid mass perturbed by the resonator. The validation of the new concept is presented in this article. An immunosensor application for the detection of a low molecular weight pollutant, the insecticide carbaryl, has been chosen as a validation model.

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QCM Technology in Biosensors

Cited by 22 publications

References 104 publications

Fully-disposable multilayered phononic crystal liquid sensor with symmetry reduction and a resonant cavity

Fully-disposable multilayered phononic crystal liquid sensor with symmetry reduction and a resonant cavity

Electrospinning for High Performance Sensors

Validation of a Phase-Mass Characterization Concept and Interface for Acoustic Biosensors

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