Pyruvate oral rehydration solution improved visceral function and survival in shock rats

Single pyruvate intake induces blood alkalization and modification of resting metabolism in humans

“…The antioxidant and anti-inflammatory properties of pyruvate [32], taken together with the results of the present study, as well as the recent animal studies [33][34][35][36], suggest its potential benefits in a clinical nutrition practice. Pyruvate diminishes cellular and organ dysfunction during hypoxic conditions and ameliorates hypoxic acidosis during hemorrhagic shock [33][34][35]; therefore, it has been suggested as a preoperative fluid supplement [35].…”

“…Pyruvate diminishes cellular and organ dysfunction during hypoxic conditions and ameliorates hypoxic acidosis during hemorrhagic shock [33][34][35]; therefore, it has been suggested as a preoperative fluid supplement [35]. Moreover, pyruvate-enriched oral rehydration solution improves intestinal absorption of water and sodium during enteral resuscitation in burns [36].…”

Effect of Intraperitoneal Resuscitation With Different Concentrations of Sodium Pyruvate on Intestinal Ischemia Reperfusion Injury in Hemorrhagic Shock Rat

“…By enhancing glucose metabolism and oxidative phosphorylation, pyruvate can increase ATP generation and lower the degree of cognitive deficits after trauma (10,18). During the process of fluid resuscitation after HS, pyruvate can correct lactic acidosis (19), and improve the prognosis and survival rate (20). Pyruvate has protective effects on intestinal mucosal ischemia-reperfusion injury (15,21).…”

Pyruvate Is Superior to Citrate in Oral Rehydration Solution in the Protection of Intestine via Hypoxia‐Inducible Factor‐1 Activation in Rats With Burn Injury

“…Additionally, the novel pyruvate-enriched ORS (Pyr-ORS) has recently demonstrated benefits for intestinal function, compared with the standard bicarbonate-based WHO-ORS, in rats subjected to burns or hemorrhagic shock. 16,17 In past decades, bicarbonate was substituted by its equivalent citrate in the WHO-ORS approach: that is, citrate-modified ORS (Cit-ORS). 18 The current study compared the effects on IMBF, major intestinal tight junction protein, and histopathological alterations by replacing citrate with pyruvate in the ORS for enteral rehydration of rats with scald injury.…”

“…17 Briefly, the segments of jejunum were permeabilized with a solution of 0.3% (wt/vol) Triton X-100 for 15 minutes and incubated with 2% normal goat serum in PBS for 60 minutes at room temperature. Then the segments were incubated overnight at 4°C with rabbit anti-ZO-1 (1:100, Invitrogen) and goat antirabbit (1:100, Invitrogen) secondary antibody conjugated to Alexa Fluor 488 for 60 minutes at room temperature, protected from light.…”