Pyrroloquinolone A, a new alkaloid and other phytochemicals from Atractylis cancellata L. with antioxidant and anticholinesterase activities

Abstract

A new alkaloid pyrroloquinolone A (1), along with fifteen known compounds 2-16 were isolated from the petroleum ether, EtOAc and n-BuOH extracts of the whole plant Atractylis cancellata L. Their structures were elucidated on the basis of extensive spectroscopic analysis including 1D-and 2D-NMR and HR-ESI-MS techniques. This is the first report of alkaloids in the genus Atractylis. Some of the isolated compounds and extracts were evaluated for their antioxidant potential (scavenging activity of DPPH and ABTS radicals, and reducing Fe +3 and Cu +2 power assays) and acetylcholinesterase and butyrylcholinesterase inhibitory activities.Compounds 8 and 11 showed good antioxidant capacity compared to ascorbic acid, BHA, and BHT used as standards, whereas compounds 1 and 2 exhibited good anticholinesterase activities compared to galantamine used as standard.

Effects and mechanisms of natural alkaloids for prevention and treatment of osteoporosis

“…There are more than ten thousand different natural alkaloids, which can be classified according to their carbon skeletal structures (Ziegler and Facchini, 2008). With the continuous development of modern medication, various biopotentials of natural alkaloids have been explored, including antioxidant (Badaoui et al, 2021), antiproliferative (Hu et al, 2018), anti-obesity (Saunders et al, 2018), antidiabetic (Jan et al, 2018), cardiovascular protection (Li et al, 2021a), anti-aging (Asokan et al, 2018), and antiinflammatory (Hu et al, 2020) effects in experimental trials and clinical applications. At present, natural alkaloids are the mainstream anti-osteoporosis drugs because of their strong efficacy and low toxicity (Ajebli et al, 2021), and some of them have been used clinically.…”

Recent Advances in One-Pot Modular Synthesis of 2-Quinolones

“…In addition, 2-quinolones are embedded as core structures in natural products [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ]. While a number of naturally occurring derivatives have been released, early reports revealed hybrid compounds that are derived from an isoprene unit and quinolones, namely hemiterpenoids [ 35 , 38 , 39 , 40 , 41 , 42 , 43 ].…”

“…Targets on this scaffold, β-adrenergic receptors [2][3][4][5], muscarinic acetylcholine receptors [6][7][8], vascular endothelial growth factor receptors [9,10], poly [ADP-ribose] polymerase-1 [11][12][13][14][15], tyrosine-protein kinases [16], and serine/threonine-protein kinases [17][18][19], have been extensively studied for decades. In addition In addition, 2-quinolones are embedded as core structures in natural products [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43]. While a number of naturally occurring derivatives have been released, early reports revealed hybrid compounds that are derived from an isoprene unit and quinolones, namely hemiterpenoids [35,38- In addition, 2-quinolones are embedded as core structures in natural products [25][26][27][28][29][30][31]…”

“…In addition In addition, 2-quinolones are embedded as core structures in natural products [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43]. While a number of naturally occurring derivatives have been released, early reports revealed hybrid compounds that are derived from an isoprene unit and quinolones, namely hemiterpenoids [35,38- In addition, 2-quinolones are embedded as core structures in natural products [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43]. While a number of naturally occurring derivatives have been released, early reports revealed hybrid compounds that are derived from an isoprene unit and quinolones, namely hemiterpenoids [35,[38][39][40][41][42][43].…”