A new aryltetralin lignan and other phytoconstituents from Atractylis humilis

Sifouane, Siham; Benabdelaziz, Imane; Benkhaled, Mohammed; Gómez‐Ruiz, Santiago; Carralero, Sandra; Haba, Hamada

doi:10.1016/j.bse.2020.104018

Cited by 4 publications

(2 citation statements)

References 41 publications

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“…In addition, compounds 3 – 44 were identified as 4-(2-formylpyrrol-1-yl) butyric acid ( 3 ), perlolyrine ( 4 ), (−)-isolariciresinol-9- O -β- d -glucopyranoside ( 5 ), (7′ S , 8 R , 8′ S )-7a-[(β- d -glucopyranosyl)-oxy] lyoniresinol ( 6 ), alangilignoside D ( 7 ), (−)-lariciresinol-9-β- d -glucopyranoside ( 8 ), 4-dimethyl heptanedioic acid ( 9 ), pyroglutamyl-phenylalanine methyl ester ( 10 ), N -acetylphenylalanine methyl ester ( 11 ), 4-hydroxy-3-methoxy benzyl-β- d -glucoside ( 12 ), isoscopoletin-β- d -glucoside ( 13 ), pinnatifidanin C III ( 14 ), pinnatifidanin C IV ( 15 ), N - trans - p -coumaroyltyramine ( 16 ), N - trans -feruloyltyramine ( 17 ), (−)- trans - N -feruloyloctopamine ( 18 ), ravifoline ( 19 ), methylprotodioscin ( 20 ), , (+)-syringaresinol-4′- O -β- d -glucopyranoside ( 21 ), (−)-pinoresinol-4- O -β- d -glucopyranoside ( 22 ), alangilignoside C ( 23 ), kaempferol-3-rutinoside ( 24 ), scopoletin ( 25 ), 4,5-di- O -caffeoyl quinic acid methyl ester ( 26 ), ferulic acid ( 27 ), p -coumaric acid ( 28 ), apocynin ( 29 ), 4-[formyl-5-(methoxymethyl)-1 H -pyrrol-1-yl] butanoic acid ( 30 ), 4-[formyl-5-(methoxymethyl)-1 H -pyrrol-1-yl] butanoate ( 31 ), trans-N -caffeoyltyramine ( 32 ), sycophantine ( 33 ), vanillic acid ( 34 ), 3-methoxy-4-hydroxyphenethanol ( 35 ), trans -caffeic acid methylate ( 36 ), 3-caffeoylquinic acid methyl ester ( 37 ), 3- O -caffeoylquinic acid ( 38 ), 3- O -feruloylquinic acid methyl ester ( 39 ), Scopoline ( 40 ), psoralen ( 41 ), quercetin ( 42 ), hesperidin ( 43 ), and rutin ( 44 ), by comparing their NMR spectroscopic data with those in the references (Figure ). Compounds 3 – 15 were isolated from the Solanum genus for the first time.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, compounds 3−44 were identified as 4-(2formylpyrrol-1-yl) butyric acid (3), 33 perlolyrine (4), 34 (−)-isolariciresinol-9-O-β-D-glucopyranoside (5), 35 (7′S, 8R, 8′S)-7a-[(β-D-glucopyranosyl)-oxy] lyoniresinol (6), 36 alangilignoside D (7), 37 (−)-lariciresinol-9-β-D-glucopyranoside (8), 38 4-dimethyl heptanedioic acid (9), 39 pyroglutamylphenylalanine methyl ester (10), 40 N-acetylphenylalanine methyl ester (11), 41 4-hydroxy-3-methoxy benzyl-β-D-glucoside ( 12), 42 isoscopoletin-β-D-glucoside (13), 43 pinnatifidanin C III ( 14), 44 pinnatifidanin C IV (15), 44 N-trans-pcoumaroyltyramine ( 16), 45 N-trans-feruloyltyramine (17), 46 (−)-trans-N-feruloyloctopamine (18), 32 ravifoline ( 19), 47 methylprotodioscin (20), 48,49 (+)-syringaresinol-4′-O-β-D-glucopyranoside (21), 50 (−)-pinoresinol-4-O-β-D-glucopyranoside ( 22), 51 alangilignoside C ( 23), 52 kaempferol-3-rutinoside (24), 53 scopoletin (25), 54 4,5-di-O-caffeoyl quinic acid methyl ester ( 26), 55 ferulic acid ( 27), 56 p-coumaric acid (28), 57 apocynin ( 29), 58 4-[formyl-5-(methoxymethyl)-1H-pyrrol-1yl] butanoic acid (30), 59 4-[formyl-5-(methoxymethyl)-1Hpyrrol-1-yl] butanoate (31), 60 trans-N-caffeoyltyramine (32), 61 sycophantine (33), 62 vanillic acid (34), 63 3-methoxy-4hydroxyphenethanol ( 35),…”

Section: ■ Resultsmentioning

confidence: 99%

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Antichilblain Components in Eggplant Based on Network Pharmacology and Biological Evaluation

Shi

Chen

et al. 2023

J. Agric. Food Chem.

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Eggplant, the fruit of Solanum melongena L. (Solanaceae), is applied externally to relieve the symptoms of chilblains in the folk in East Asia. However, the mechanisms and biological ingredients are not clear. A network pharmacology approach was used to shed light on the mechanisms of eggplant against chilblains, which illustrated that anti-inflammation and antioxidation are mainly involved in the curative effects. Bioassay-guided assays led to the isolation of 44 ingredients (1–44), including two new natural compounds (1–2) and 42 known compounds. Thirteen compounds (3–15) were first reported from the Solanum genus. The anti-inflammatory and antioxidative effects of all isolates were evaluated, and the results showed that 11 compounds have anti-inflammatory activity and 27 have antioxidant activity. Fatty acids, flavonoids, alkaloids, phenolic acids, saponins, and lignans from eggplant have certain anti-inflammatory and antioxidant effects. These results provide a scientific basis for eggplant to treat chilblains.

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