Pyrrolidinyl PNA polypyrrole/silver nanofoam electrode as a novel label-free electrochemical miRNA-21 biosensor

Kangkamano, Tawatchai; Numnuam, Apon; Limbut, Warakorn; Kanatharana, Proespichaya; Vilaivan, Tirayut; Thavarungkul, Panote

doi:10.1016/j.bios.2017.11.024

Cited by 79 publications

(32 citation statements)

References 42 publications

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“…Consequently, the possible analyses of the biosensor without RNA extraction and or amplication showed the potential usefulness of the sensor for the prognosis as well as diagnosis of cancer in clinical applications. 93…”

Section: Electrochemical Sensingmentioning

confidence: 99%

Recent developments in conducting polymers: applications for electrochemistry

et al. 2020

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Section: Electrochemical Sensingmentioning

confidence: 99%

Recent developments in conducting polymers: applications for electrochemistry

et al. 2020

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“…Another example, where the charge accumulation is exploited for miR-21 detection, was recently reported by Kangkamano et al [60]. This platform is based on silver nanostructures and relies on pyrrolidinyl PNA systems consisting of a D-prolyl-2-aminocyclopentanecarboxylic acid backbone (acpcPNA) developed in the Vilaivan group [61].…”

Section: Electrochemical Detection Methodologies Based On Hybridizationmentioning

confidence: 99%

“…(A) Field-effect transistor (FET)-based biosensor introduced in[59]. (B) Silver nanofoam (AgNF)-based biosensor decorated with acpcPNAs shown in[60]. (C) A 384-channel array on the Au/Cr surface based on the oxidation current of ferricyanide, described in[62].…”

mentioning

confidence: 99%

PNA-Based MicroRNA Detection Methodologies

2020

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MicroRNAs (miRNAs or miRs) are small noncoding RNAs involved in the fine regulation of post-transcriptional processes in the cell. The physiological levels of these short (20–22-mer) oligonucleotides are important for the homeostasis of the organism, and therefore dysregulation can lead to the onset of cancer and other pathologies. Their importance as biomarkers is constantly growing and, in this context, detection methods based on the hybridization to peptide nucleic acids (PNAs) are gaining their place in the spotlight. After a brief overview of their biogenesis, this review will discuss the significance of targeting miR, providing a wide range of PNA-based approaches to detect them at biologically significant concentrations, based on electrochemical, fluorescence and colorimetric assays.

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“…[11][12][13] Polymers with conjugated chains are frequently used because of their low oxidation potential, electronic and ionic conductivity and porous morphology. 14,15 Due to these advantages, a scheme was proposed using polymers as carriers to deposit metal nanoparticles in order to fabricate polymer/metal nanocomposite-modied electrodes. These modied electrodes can enhance the stability of the combination of the nanometre-sized material and electrode base, lessen the tendency for the particles to reunify and improve the catalytic properties of the nanocomposites.…”

Section: Introductionmentioning

confidence: 99%