Pyrrolidine dithiocarbamate-induced activation of ERK and increased expression of c-Fos in mouse embryonic stem cells

Kim, Young Eun; Park, Jeong-A; Nam, Ki-Hoan; Kwon, Hyung‐Joo; Lee, Younghee

doi:10.5483/bmbrep.2009.42.3.148

Cited by 5 publications

(4 citation statements)

References 32 publications

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“…Moreover, previous studies have shown that Erk1/2 MAPK plays an important role in activation of the AP1 transcription complex comprising c-Fos and c-Jun family members (7,18,26,37,53,57). Our current studies demonstrate that LA CS induced an increase in Erk1/2 MAPK phosphorylation in Caco-2 cells within 1 h that persisted for 24 h. Parallel to an increase in Erk1/2 MAPK phosphorylation at 24 h, LA CS also induced protein expression levels of c-Fos and c-Jun in Caco-2 cells.…”

Section: Discussionmentioning

confidence: 99%

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Lactobacillus acidophilusstimulates intestinal P-glycoprotein expression via a c-Fos/c-Jun-dependent mechanism in intestinal epithelial cells

Priyamvada

Anbazhagan

Kumar

et al. 2016

American Journal of Physiology-Gastrointestinal and Liver Physi

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Section: Discussionmentioning

confidence: 99%

“…Previous reports show that c-Fos and c-Jun transcription factors are activated by the Erk1/2 MAPK pathway (7,18,26,37,53,57). Our previous studies showed that stimulation of Pgp function by LA CS was mediated via an Erk1/2 MAPK pathway (48).…”

Section: La Cs Induces Erk1/2 Mapk Activation and C-fos Or C-jun Protmentioning

confidence: 99%

Lactobacillus acidophilusstimulates intestinal P-glycoprotein expression via a c-Fos/c-Jun-dependent mechanism in intestinal epithelial cells

Priyamvada

Anbazhagan

Kumar

et al. 2016

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…Differentiation was shown to be promoted in mouse ESC when NF-kB proteins were inhibited by pyrrolidine dithiocarbamate (PDTC), promoting ERK1/2 signaling and, therefore, differentiation. 80 In this situation, the authors described that FOS protein was also present. This relation suggests that the presence of FOS and the inhibition of NF-kB are inadequate for cellular reprogramming.…”

Section: Paper Molecular Biosystemsmentioning

confidence: 99%

Combining small molecules for cell reprogramming through an interatomic analysis

Feltes

Bonatto

2013

Mol. BioSyst.

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The knowledge available about the application and generation of induced pluripotent stem cells (iPSC) has grown since their discovery, and new techniques to enhance the reprogramming process have been described. Among the new approaches to induce iPSC that have gained great attention is the use of small molecules for reprogramming. The application of small molecules, unlike genetic manipulation, provides for control of the reprogramming process through the shifting of concentrations and the combination of different molecules. However, different researchers have reported the use of "reprogramming cocktails" with variable results and drug combinations. Thus, the proper combination of small molecules for successful and enhanced reprogramming is a matter for discussion. However, testing all potential drug combinations in different cell lineages is very costly and time-consuming. Therefore, in this article, we discuss the use of already employed molecules for iPSC generation, followed by the application of systems chemo-biology tools to create different data sets of protein-protein (PPI) and chemical-protein (CPI) interaction networks based on the knowledge of already used and new reprogramming cocktail combinations. We further analyzed the biological processes associated with PPI-CPI networks and provided new potential protein targets to be inhibited or expressed for stem cell reprogramming. In addition, we applied a new interference analysis to prospective targets that could negatively affect the classical pluripotency-associated factors (SOX2, NANOG, KLF4 and OCT4) and thus potentially improve reprogramming protocols.

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“…Pomc-a , pomc-b , and pomc-c cDNA have been cloned in Jpn flounder (Kim et al, 2009 and accession number ACG68732); the original terms POMC-II, POMC-I, and POMC-III in the paper correspond to POMC-A, POMC-B, and POMC-C, respectively. We observed the expression of these three genes in the pituitary and those of pomc-c in Jpn flounder skin.…”

Section: Pomc and MC Peptides In Floundersmentioning

confidence: 99%

Melanocortin Systems on Pigment Dispersion in Fish Chromatophores

Kobayashi¹,

Mizusawa²,

Saito³

et al. 2012

Front. Endocrin.

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α-Melanocyte-stimulating hormone (α-MSH) is responsible for pigment dispersion in the chromatophores of fish and other tetrapods such as amphibians and reptiles. Recently, we discovered that α-MSH did not always stimulate pigment dispersion because this hormonal peptide exerted no effects on the melanophores of flounders. We assumed that the reduction of α-MSH activity was related to the co-expression of different α-MSH receptor subtypes – termed melanocortin receptors (MCR) – a member of G-protein-coupled receptors (GPCR) – based on several reports demonstrating that GPCR forms heterodimers with various properties that are distinct from those of the corresponding monomers. In this review, we summarize the relationships between the pigment-dispersing activity of α-MSH-related peptides, molecular forms of α-MSH-related peptides, and mcr subtypes expressed in fish chromatophores.

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Pyrrolidine dithiocarbamate-induced activation of ERK and increased expression of c-Fos in mouse embryonic stem cells

Abstract: Pyrrolidine dithiocarbamate (PDTC) is a stable anti-oxidant or pro-oxidant, depending on the situation, and it is widely used to inhibit the activation of NF-κB. We recently reported that PDTC activates the MIP-2 gene in a NF-κB-independent and c-Jun

Cited by 5 publications

References 32 publications

Lactobacillus acidophilusstimulates intestinal P-glycoprotein expression via a c-Fos/c-Jun-dependent mechanism in intestinal epithelial cells

Lactobacillus acidophilusstimulates intestinal P-glycoprotein expression via a c-Fos/c-Jun-dependent mechanism in intestinal epithelial cells

Combining small molecules for cell reprogramming through an interatomic analysis

Melanocortin Systems on Pigment Dispersion in Fish Chromatophores

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