Pyroglyphid House Dust Mite Allergens

Abstract

Mites of the family Pyroglyphidae are the most important source of house dust mite allergens. A small number of allergens, namely those of groups 1, 2, 4, 5 and 7 constitute the known major and mid-potency specificities, with possible important contributions of the groups 11, 14 and 15 requiring further definition. Most of the allergens can be identified by sequence homologies and the structures of the major allergens have been solved. There are however challenges in determining the nature of the group 5 and 7 allergens and in obtaining detailed structures of the significant allergens to be used for genetic engineering.

Varying Allergen Composition and Content Affects the in vivo Allergenic Activity of Commercial <b><i>Dermatophagoides pteronyssinus</i></b> Extracts

“…have been found to be the most important allergen source in house dust [2]. House-dust mites (HDMs) represent one of the most common causes of allergy worldwide, against which more than 50% of allergic patients are sensitized [3] and in which, so far, more than 20 allergens have been identified [4,5]. …”

Molecular characterization of Der p 10: a diagnostic marker for broad sensitization in house dust mite allergy

“…Both allergens are recognized by more than 90% of HDM-allergic patients and are considered as the major HDM allergens [5]. More than 20 other mite allergens have been identified but their importance for mite allergy has only partly been studied [9]. Among these allergens, Der p 10, a tropomyosin, has received attention because it occurs as a cross-reactive allergen in invertebrates [10] and, in particular, in seafood, where it has been described as an important allergen responsible for severe systemic anaphylaxis [11].…”

Identification of Allergenic Component Tyr p 8 from Tyrophagus putrescentiae and Cross-Reactivity with Der p 8

“…D. pteronyssinus prefers temperate/tropical coastal regions, whereas D. farinae is more abundant in continental climates. The allergens of D. pteronyssinus and D. farinae typically have 15 to 20% amino acid sequence disparity, and although they are immunologically cross-reactive, they also have unique epitopes (18). The importance of using extracts tailored to the species prevalent in the local environment is not known and is difficult to ascertain because of the variation in extracts obtained from the same species.…”