Pyriproxyfen induced impairment of reproductive endocrine homeostasis and gonadal histopathology in zebrafish (Danio rerio) by altered expression of hypothalamus-pituitary-gonadal (HPG) axis genes

Maharajan, Kannan; Muthulakshmi, Sellamani; Karthik, Chinnannan; Nataraj, Bojan; Nambirajan, Kanthan; Hemalatha, Devan; Jiji, Swaminathan; Kadirvelu, K.; Liu, Ke-chun; Ramesh, Mathan

doi:10.1016/j.scitotenv.2020.139496

Cited by 37 publications

(17 citation statements)

References 53 publications

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“…An altered expression of hypothalamus-pituitary-gonadal axis genes was also recorded for both sexes [ 65 ]. Furthermore, embryological exposure of zebrafish to Pyr ended with a high mortality rate and craniofacial deformities at concentrations higher than 5.2 µM [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

Vitamin C Attenuates Oxidative Stress and Behavioral Abnormalities Triggered by Fipronil and Pyriproxyfen Insecticide Chronic Exposure on Zebrafish Juvenile

et al. 2020

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Chronic exposure to synthetic insecticides in the early life of a child can lead to a series of disorders. Several causes as parental age, maternal smoking, birth complications, and exposure to toxins such as insecticides on childhood can lead to Autism spectrum disorder (ASD) occurrence. The aim of this study was to evaluate the potential protective role of vitamin C (Vit. C) from children’s supplements after 14 days chronic exposure to insecticide mixture fipronil (Fip) + pyriproxyfen (Pyr) on juvenile zebrafish for swimming performances, social behavior and oxidative stress associated with ASD model. Juvenile (14–17 mm) wild-type AB zebrafish (Danio rerio) (45 days) were exposed to relevant concentrations: vit. C (25 µg L−1), Fip (600 µg L−1/1.372 μM) + Pyr (600 µg L−1/1.89 μM), and [Fip (600 µg L−1/1.372 μM) + Pyr (600 µg L−1 /1.89 μM)] + vit. C (25 µg L−1). Our results showed that insecticides can disturb the social behavior of zebrafish during 14 days of the administration, decreased the swimming performances, and elevated the oxidative stress biomarkers of SOD (superoxide dismutase), GPx (glutathione peroxidase), and MDA (malondialdehyde). The vitamin C supplement significantly attenuated the neurotoxicity of insecticide mixture and oxidative stress. This study provides possible in vivo evidence to show that vitamin C supplements could attenuate oxidative stress and brain damage of fipronil and pyriproxyfen insecticide chronic exposure on zebrafish juvenile.

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Section: Discussionmentioning

confidence: 99%

Vitamin C Attenuates Oxidative Stress and Behavioral Abnormalities Triggered by Fipronil and Pyriproxyfen Insecticide Chronic Exposure on Zebrafish Juvenile

et al. 2020

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“…Vitamin C supplementation significantly increased SOD and GPx levels and reduced MDA levels compared to those in controls ( p < 0.05). Reduced oxidative stress induced by the insecticide mixture fipronil (Fip) + pirimiphos-methyl (Pyr), reduced insecticide neurotoxicity, and improved motility in juvenile zebrafish, possibly by mechanisms that alter the expression of hypothalamic–pituitary–gonadal axis genes [ 129 ] and increase cortisol levels [ 130 ].…”

Section: Nutritional Modulation Measures To Mitigate Oxidative Stressmentioning

confidence: 99%

Research Progress on Oxidative Stress and Its Nutritional Regulation Strategies in Pigs

Hao

Xing

2021

Animals

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Oxidative stress refers to the dramatic increase in the production of free radicals in human and animal bodies or the decrease in the ability to scavenging free radicals, thus breaking the antioxidation–oxidation balance. Various factors can induce oxidative stress in pig production. Oxidative stress has an important effect on pig performance and healthy growth, and has become one of the important factors restricting pig production. Based on the overview of the generation of oxidative stress, its effects on pigs, and signal transduction pathways, this paper discussed the nutritional measures to alleviate oxidative stress in pigs, in order to provide ideas for the nutritional research of anti-oxidative stress in pigs.

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“…It has been reported that pyriproxyfen has activity against Spodoptera littoralis and Eretmocerus mundus Mercet (including pupae) 26,27 . The toxicity of pyriproxyfen to nontarget organisms has also been studied and it has been found to pose a high risk to Danio rerio and Daphnia magna 28–30 . The sublethal and lethal effects of pyriproxyfen to honeybees have also been reported 31 .…”

Section: Introductionmentioning

confidence: 99%

Systemic assessment of the chiral insecticide pyriproxyfen in a citrus nectar source system: Stereoselective degradation, biological effect and exposure risk

Tong

Yang

Sun

et al. 2022

Pest Management Science

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BACKGROUND: Balancing the safety and efficiency of chiral pesticides can help protect pollinators. We evaluated the stereoselective behavior, bioactivity, toxicity and exposure risk of the chiral insecticide pyriproxyfen in a citrus nectar system. RESULTS: Density functional theory (DFT) and ultra-performance liquid chromatography tandem mass spectroscopy (UPLC-MS/ MS) were applied for absolute configuration appraisal and chiral analysis validation, respectively. The recoveries ranged from 72.3% to 100.5% with an relative standard deviation (RSD) ranging from 1.2% to 9.7%. In a field trial, we determined insecticide half-lives in citrus leaves and flowers, which were 7.0 and 8.6 days for R-(+)-pyriproxyfen, and 11.7 and 14.7 days for S-(−)-pyriproxyfen, respectively. We found that the bioactivity of R-(+)-pyriproxyfen was 3.39 and 2.37 times higher than S-(−)-pyriproxyfen against Unaspis yanonensis and Diaphorina citri nymphs, respectively. S-(−)-pyriproxyfen had 3.8 times higher acute toxicity than R-(+)-pyriproxyfen on Apis mellifera L., and its exposure risk was moderate based on the hazard quotient.CONCLUSION: The phenomenon of stereoselective degradation and biological effect demonstrated that the high-risk stereoisomer of S-(−)-pyriproxyfen degraded more slowly than R-(+)-pyriproxyfen, but R-(+)-pyriproxyfen with better efficiency for target. Therefore, an increased duration of R-(+)-pyriproxyfen activity on citrus was beneficial for efficacy. Our results could guide the scientific application and evaluation of chiral pesticides on nectar plants.

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Pyriproxyfen induced impairment of reproductive endocrine homeostasis and gonadal histopathology in zebrafish (Danio rerio) by altered expression of hypothalamus-pituitary-gonadal (HPG) axis genes

Cited by 37 publications

References 53 publications

Vitamin C Attenuates Oxidative Stress and Behavioral Abnormalities Triggered by Fipronil and Pyriproxyfen Insecticide Chronic Exposure on Zebrafish Juvenile

Vitamin C Attenuates Oxidative Stress and Behavioral Abnormalities Triggered by Fipronil and Pyriproxyfen Insecticide Chronic Exposure on Zebrafish Juvenile

Research Progress on Oxidative Stress and Its Nutritional Regulation Strategies in Pigs

Systemic assessment of the chiral insecticide pyriproxyfen in a citrus nectar source system: Stereoselective degradation, biological effect and exposure risk

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