Pyrimido [4,5-d]pyrimidines. Part I

Multicomponent synthesis of dispiroheterocycles using a magnetically separable and reusable heterogeneous catalyst

“…The presence of water content in solvent facilitates the reaction probably through non-covalent interactions. 25 Pyrimido[4,5-d]pyrimidines 26 are considered annulated uracils and constitute an important class of biologically signicant molecules because of their structural relationship with purine and pteridine heterocyclic systems. The compounds incorporating pyrimidopyrimidinering system have been reported to exhibit diverse activities such as antimicrobial, 27 hepatoprotective, 28 antiviral, 28 antibacterial, 28 anticancer activity 29 and anti-HIV activity.…”

Bicyclic 6 + 6 systems: the chemistry of pyrimido[4,5-d]pyrimidines and pyrimido[5,4-d]pyrimidines

“…reported methods have several disadvantages, for example, the starting materials are not readily accessible or complex techniques, harsh conditions or multistep processes are required. 42,43 The synthesis of the pyrimido [4,5-d]pyrimidines was rst reported by Taylor et al 18 who reported the reaction of the 4aminopyrimidine-5-carboxamides with 4-amino-5cyanopyrimidines and the application of the products as diuretic agents. Burch et al 44 synthesized a series of N,Ndisubstituted-2-(5-nitrofuran-2-yl)pyrimido [4,5-d]pyrimidin-4amines by treating N-(5-cyanopyrimidin-4-yl)-5-nitrofuran-2carboxamide with sulfuric acid followed by heating, intramolecular cyclization and subsequent chlorination with phosphorous pentasulde/thionyl chloride and nucleophilic substitution with amines.…”

A convenient route for synthesis and antimicrobial evaluation of bis (diimino benzothiazolo pyrimido pyrimidines)

“…, vasodilators 10 , antiallergic 11 and hypersensitive agent 12 , more over they display potent inhibitory properties regarding tyrosine kinase domain of epidermal growth factor receptor 13 . Various researcher reported pyrimido pyrimidine explore the antitumor 14 , antiviral 15 , antioxidant 16 , antifungal 17 and hepatoprotective activities 18 .…”