Bicyclic 6 + 6 systems: the chemistry of pyrimido[4,5-d]pyrimidines and pyrimido[5,4-d]pyrimidines

Abstract

The present investigation provides an overview of the chemistry of pyrimido[4,5-d]pyrimidines and pyrimido[5,4-d]pyrimidines. The synthetic methods, reactivities, and biological applications are described.

Insights into the recent progress in the medicinal chemistry of pyranopyrimidine analogs

“…Thus, this study has been undertaken as a persistence of our previous programs and studies on highlighting the chemistry of heterocyclic compounds with miscellaneous biological activities and their significance in the fields of medicinal and pharmaceutical chemistry. [52][53][54][55][56][57][58][59] Our program deals with highlighting and exploring the prosperous medicinal chemistry of pyranopyrimidine compounds, particularly pyranoij2,3-d]pyrimidines, in the last five years. The topic of this research is an extension of our previous study that is interesting to highlight the recent methods and progress in the multicomponent synthesis of heterocycleincorporated pyranoij2,3-d]pyrimidine motif under different conditions.…”

Synthetic strategies of heterocycle-integrated pyridopyrimidine scaffolds supported by nano-catalysts

“…The objective of the present review is to highlight the diverse nano-catalysts applied to prepare heterocycles integrated pyridopyrimidine core. Through our preceding work regarding the signicance of reactive synthons in the synthesis of many heterocycles, 58,59 and many reviews that deliberated the chemistry fused pyrimidines, [60][61][62][63][64][65][66][67] and pyridopyrimidines, [68][69][70] we herein highlight the advancements in the synthetic strategies of heterocycle-integrated pyridopyrimidine scaffolds supported in nano-catalysis. The theme of the research is apprehensive with reviewing the mechanisms of the diverse reactions, nanocatalyst preparation, the benet of the used nanocatalyst, the nanocatalyst's efficient role for improved product yields, and increased reaction rates.…”

Design, step-economical diversity-oriented synthesis of an N-heterocyclic library containing a pyrimidine moiety: discovery of novel potential herbicidal agents

“…Pyrimidine as a core structure widely exists in natural products. 1 It has shown prominent pharmaceutical and agricultural activity, 2 and acts as anti-cancer, 3 anti-HIV, 4 and anti-microbial 5 agents, insecticides, 6 fungicides 7 and herbicides. 8 4,6-Dimethoxypyrimidine is a key structural motif commonly employed in herbicide molecular design in the quest for novel highly active herbicides 9 ( Fig.…”