Pyrethroids and the synergist piperonyl-butoxide (PBO) affect T-cells and basophils

Pyrethroid insecticides influence the signal transduction in T helper lymphocytes from atopic and nonatopic subjects

“…In addition, recent works have demonstrated increased sensitivity of allergic patients to S-bioallethrin [24,25].…”

Malathion, Lindane, and Piperonyl Butoxide, Individually or in Combined Mixtures, Induce Immunotoxicity via Apoptosis in Murine Splenocytes In Vitro

“…The pesticides examined in this study have been previously shown individually to dysregulate or suppress immune function. [9][10][11][12][13][14] The effect of these xenobiotics on immune cells is of particular interest, because it is known that immune response is governed by a series of delicately balanced, complex, multicellular physiological mechanisms that at times are vulnerable to very low levels of chemical insult. 4,15 One possible outcome of immunotoxic effects is cell death resulting from either apoptosis or necrosis.…”