1990
DOI: 10.1001/archderm.126.2.213
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Pyrethrins and pyrethroids in dermatology

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Cited by 31 publications
(18 citation statements)
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“…However, we are concerned about the possible emergence of resistance to these topical therapies with such a program. Although resistance of head lice (Pediculus capitis) to 1% permethrin has been widely reported [2,18], there has to date been no documented clinical evidence of tolerance of scabies mites to 5% permethrin [19], although we reported evidence for increasing in vitro killing time [7]. Our in vitro testing also showed that 25% benzyl benzoate killed scabies mites more quickly than did 5% permethrin [7], but clinical resistance to benzyl benzoate has been suspected elsewhere [20].…”
Section: Discussionmentioning
confidence: 48%
“…However, we are concerned about the possible emergence of resistance to these topical therapies with such a program. Although resistance of head lice (Pediculus capitis) to 1% permethrin has been widely reported [2,18], there has to date been no documented clinical evidence of tolerance of scabies mites to 5% permethrin [19], although we reported evidence for increasing in vitro killing time [7]. Our in vitro testing also showed that 25% benzyl benzoate killed scabies mites more quickly than did 5% permethrin [7], but clinical resistance to benzyl benzoate has been suspected elsewhere [20].…”
Section: Discussionmentioning
confidence: 48%
“…3,15 Over a half a century ago, PBO was added as a synergist to the relatively expensive pyrethrum extract, so less extract was needed to produce the same insecticidal activity. 24 Although originally PBO was added purely for financial reasons, it is now known to slow down the development of resistance at the mixed function oxidase (MFO) pathway. 3 The difference in efficacy between undiluted and diluted Nix is important.…”
Section: Commentmentioning
confidence: 99%
“…DEET is highly permeable to the skin and has been studied Selim et al, 1995) for its metabolism and toxicity. Permethrin has been used to impregnate the clothing of military personnel as protection against pestiferous and vector insects (Taplin and Meinking, 1990). It is possible that combined exposure to these chemicals would result in differential effects than exposure to single chemicals.…”
Section: Discussionmentioning
confidence: 99%