Pyrethrins and pyrethroids in dermatology

Taplin, David

doi:10.1001/archderm.126.2.213

Cited by 32 publications

(21 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, we are concerned about the possible emergence of resistance to these topical therapies with such a program. Although resistance of head lice (Pediculus capitis) to 1% permethrin has been widely reported [2,18], there has to date been no documented clinical evidence of tolerance of scabies mites to 5% permethrin [19], although we reported evidence for increasing in vitro killing time [7]. Our in vitro testing also showed that 25% benzyl benzoate killed scabies mites more quickly than did 5% permethrin [7], but clinical resistance to benzyl benzoate has been suspected elsewhere [20].…”

Section: Discussionmentioning

confidence: 48%

First Documentation of In Vivo and In Vitro Ivermectin Resistance in Sarcoptes scabiei

Currie

Harumal

McKinnon

et al. 2004

Clinical Infectious Diseases

256

151

View full text Add to dashboard Cite

Ivermectin is increasingly being used to treat scabies, especially crusted (Norwegian) scabies. However, treatment failures, recrudescence, and reinfection can occur, even after multiple doses. Ivermectin resistance has been documented for some intestinal helminths in animals with intensive ivermectin exposure. Ivermectin resistance has also been induced in arthropods in laboratory experiments but, to date, has not been documented among arthropods in nature. We report clinical and in vitro evidence of ivermectin resistance in 2 patients with multiple recurrences of crusted scabies who had previously received 30 and 58 doses of ivermectin over 4 and 4.5 years, respectively. As predicted, ivermectin resistance in scabies mites can develop after intensive ivermectin use.

show abstract

Section: Discussionmentioning

confidence: 48%

First Documentation of In Vivo and In Vitro Ivermectin Resistance in Sarcoptes scabiei

Currie

Harumal

McKinnon

et al. 2004

Clinical Infectious Diseases

256

151

View full text Add to dashboard Cite

show abstract

“…3,15 Over a half a century ago, PBO was added as a synergist to the relatively expensive pyrethrum extract, so less extract was needed to produce the same insecticidal activity. 24 Although originally PBO was added purely for financial reasons, it is now known to slow down the development of resistance at the mixed function oxidase (MFO) pathway. 3 The difference in efficacy between undiluted and diluted Nix is important.…”

Section: Commentmentioning

confidence: 99%

Comparative In Vitro Pediculicidal Efficacy of Treatments in a Resistant Head Lice Population in the United States

Meinking¹,

Serrano²,

Hard³

et al. 2002

Arch Dermatol

122

114

View full text Add to dashboard Cite

“…DEET is highly permeable to the skin and has been studied Selim et al, 1995) for its metabolism and toxicity. Permethrin has been used to impregnate the clothing of military personnel as protection against pestiferous and vector insects (Taplin and Meinking, 1990). It is possible that combined exposure to these chemicals would result in differential effects than exposure to single chemicals.…”

Section: Discussionmentioning

confidence: 99%

Toxic Interactions of Prophylactic Drugs and Pesticides

Abou‐Donia¹

2003

View full text Add to dashboard Cite

Approved for public release; Distribution unlimited 12b. DISTRIBUTION CODE ABSTRACT (Maximum 200 Words/The goal of the present project is to define the mechanisms of neurotoxic interactions following exposure to pyridostigmine bromide (PB, 0.13, 1.3,13 mg/gk in water, oral), DEET (4.0, 40.0, 400.0 mg/kg in ethanol, dermal), and permethrin (0.013, 0.13, 1.3 mg/kg in ethanol, dermal) in male Sprauge-Dawley rats. The results are summarized below. 1. Combined exposure to the three test compounds for 28 days, alone or with stress produced neuropathological alterations in the brain and hepatic lesions. 2. The same treatments increased the permeability of the blood brain barrier (BBB), as assessed by [ 3 H]hexamethonium iodide uptake and horseradish peroxidase (HRP) staining.3. Specific brain region exhibited decreased activity of AChE and ligand binding of m2 muscarinic acetylcholine receptors. 4. Exposure to DEET alone, or with permethrin significantly increased urinary excretion of 8-hydroxy-2'-deoxyguanosine. 5. Within 30 minutes of dermal application of 400 mg/kg DEET alone, or in combination with 1.3 mg/kg permethrin, 55% DEET and 38% permethrin was absorbed. Distribution of permethrin in tissues was slower than DEET.Combined application to both chemicals increased AUC for DEET but did not affect AUC FlasT . a of permethrin. The goal of this project is to evaluate the possible interaction between DEET, permethrin and pyridostigmine bromide (PB) and the biological and pathological consequences of such interactions. Our standing hypothesis is that combined exposure to a mixture of chemicals would have enhanced, and in some cases deterimental toxicological effects than exposure with single chemical. SUBJECT TERMS B) ApproachWe have been testing the stated hypothesis that interactions between combined chemical exposure would result in greater toxicological and pathological changes, and certain environmental modifying factors such as stress would modulate the toxic effects in combined exposure scenario. In the previous year we have carried out dose-response studies ranging from 0.1-10 x the estimated human exposure on DEET, permethrin and PB. In those studies we carried out neurobehavioral as well as neurochemical assessment following exposure to a single or multiple chemicals (See the manuscripts in Appendix). In the current studies, we have focused on the pathological consequences of sub-chronic exposure to single chemical or combined concurrent exposure. Additionally, we studied the effect of one environmental modifier, stress on the neurotoxicity associated with concurrent exposure to PB, DEET and permethrin. The pathological changes were studied by immunohistochemical evaluation of microtubule-associated protein-2 (MAP-2), glialfibrillary acidic protein (GFAP), and microglial activation by lectin binding. Furthermore, we evaluated the possible mechanism(s) of neurotoxic effects of single or combined exposure by assessing the permeability of blood-brain barrier (BBB) and evaluating 8-hydroxy-2'-deoxyguanosine by ...

show abstract

Pyrethrins and pyrethroids in dermatology

Cited by 32 publications

References 0 publications

First Documentation of In Vivo and In Vitro Ivermectin Resistance in Sarcoptes scabiei

First Documentation of In Vivo and In Vitro Ivermectin Resistance in Sarcoptes scabiei

Comparative In Vitro Pediculicidal Efficacy of Treatments in a Resistant Head Lice Population in the United States

Toxic Interactions of Prophylactic Drugs and Pesticides

Contact Info

Product

Resources

About