Pyrene induces a reduction in midbrain size and abnormal swimming behavior in early-hatched pufferfish larvae

Sugahara, Yuki; Kawaguchi, Masahumi; Itoyama, Tatsuya; Kurokawa, Daisuke; Tosa, Yasuhiko; Kitamura, Shin-Ichi; Handoh, Itsuki C.; Nakayama, Kei; Murakami, Yasunori

doi:10.1016/j.marpolbul.2014.04.022

Cited by 6 publications

(3 citation statements)

References 51 publications

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“…The longer exposure (8 days more than our longest exposure) may explain the difference with our study. Effects on survival, growth or deformity index were observed for pyrene and phenanthrene in other various fish species ELS at concentrations ranging from 20 to 200 µg.L -1 (Hendon et al, 2008;Mu et al, 2012;Sugahara et al, 2014). However, possible differences in species sensitivity to PAHs, toxicokinetics, life stages and more generally experimental designs makes the comparison among those different studies and the present one quite difficult.…”

Section: Pahs Caused Almost No Detectable Deformities or Growth Retar...mentioning

confidence: 98%

Retene, pyrene and phenanthrene cause distinct molecular-level changes in the cardiac tissue of rainbow trout (Oncorhynchus mykiss) larvae, part 1 – Transcriptomics

Rigaud

Eriksson

Krasnov

et al. 2020

Science of The Total Environment

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Section: Pahs Caused Almost No Detectable Deformities or Growth Retar...mentioning

confidence: 98%

Retene, pyrene and phenanthrene cause distinct molecular-level changes in the cardiac tissue of rainbow trout (Oncorhynchus mykiss) larvae, part 1 – Transcriptomics

Rigaud

Eriksson

Krasnov

et al. 2020

Science of The Total Environment

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“…The primary petroleum product constituents most toxic to aquatic organisms are polycyclic aromatic hydrocarbons (PAHs), which due to their lipophilic character (low solubility), tend to be adsorbed onto particles in marine water and ultimately accumulate in sediments (Antizar-Ladislao 2009;Sugahara et al 2014). Although naturally occurring, PAHs are mainly generated from anthropogenic sources.…”

Section: Introductionmentioning

confidence: 99%

Occurrence and distribution of polycyclic aromatic hydrocarbons in surface sediments of San Diego Bay marinas

Neira

Cossaboon

Mendoza

et al. 2017

Marine Pollution Bulletin

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Polycyclic aromatic hydrocarbons (PAHs) have garnered much attention due to their bioaccumulation, carcinogenic properties, and persistence in the environment. Investigation of the spatial distribution, composition, and sources of PAHs in sediments of three recreational marinas in San Diego Bay, California revealed significant differences among marinas, with concentrations in one site exceeding 16,000ngg. 'Hotspots' of PAH concentration suggest an association with stormwater outfalls draining into the basins. High-molecular weight PAHs (4-6 rings) were dominant (>86%); the average percentage of potentially carcinogenic PAHs was high in all sites (61.4-70%) but ecotoxicological risks varied among marinas. Highly toxic benzo(a)pyrene (BaP) was the main contributor (>90%) to the total toxic equivalent quantity (TEQ) in marinas. PAHs in San Diego Bay marina sediments appear to be derived largely from pyrogenic sources, potentially from combustion products that reach the basins by aerial deposition and stormwater drainage from nearby streets and parking lots.

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“…The study of Sugahara et al [ 82 ] showed the effect of pyrene and phenanthrene on neurodevelopment and behavioural function in an early hatched putterfish larvae experimental model. The behavioural analysis showed that exposure to 100 ppb of pyrene impaired swimming trajectory and reduced optic tectum.…”

Section: Discussionmentioning

confidence: 99%

Neurotoxicity of Polycyclic Aromatic Hydrocarbons: A Systematic Mapping and Review of Neuropathological Mechanisms

Olasehinde

Olaniran

2022

Toxics

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Several studies present the neurotoxic effects of polycyclic aromatic hydrocarbons (PAHs), a class of environmental pollutants capable of causing neurological deficits. However, a collective review approach to this research topic is scarce. This study presents the effect of PAHs on the central nervous system using a bibliometric approach. The neuropathological mechanisms of PAHs are also highlighted. Published articles were searched for in the Scopus and Web of Science databases from January 1979 to December 2020 using the keywords ‘polycyclic aromatic hydrocarbons’ and ‘neurotoxicity’. The total number of documents retrieved from both databases was 338. Duplicated documents (80) were excluded and 258 articles were used for the final analysis. Our findings revealed that there has been a significant increase in research outputs on this topic in the last ten years. The countries with the highest scientific productivity in this area are USA, China, France and Italy. The result also showed that, in the past few years, global scientific output in research relating to PAH neurotoxicity focused on neurodegeneration, cholinergic function, neurodevelopmental toxicity, behavioural studies, oxidative stress, neuroprotection and therapeutic intervention using different experimental models, including zebrafish, neuronal cell lines, Caenorhabditis elegans and rats. Recent studies also revealed the neuroprotective roles of some natural products against PAH-induced neurotoxicity. However, more investigation involving clinical trials is required to emphasize the observed neurotoxic effects.

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Pyrene induces a reduction in midbrain size and abnormal swimming behavior in early-hatched pufferfish larvae

Cited by 6 publications

References 51 publications

Retene, pyrene and phenanthrene cause distinct molecular-level changes in the cardiac tissue of rainbow trout (Oncorhynchus mykiss) larvae, part 1 – Transcriptomics

Retene, pyrene and phenanthrene cause distinct molecular-level changes in the cardiac tissue of rainbow trout (Oncorhynchus mykiss) larvae, part 1 – Transcriptomics

Occurrence and distribution of polycyclic aromatic hydrocarbons in surface sediments of San Diego Bay marinas

Neurotoxicity of Polycyclic Aromatic Hydrocarbons: A Systematic Mapping and Review of Neuropathological Mechanisms

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