Pyramidal tract degeneration in astrocytoma

Lahrmann, Heinz; Horvath-Mechtler, Barbara; Hitzenberger, Peter; Oberndorfer, Stefan; Struhal, Walter; Grisold, Wolfgang

doi:10.1007/s11060-004-2342-6

Cited by 4 publications

(4 citation statements)

References 3 publications

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“…Thus, we believe that this discretization step highlights in the final SD maps those differences between the two approaches which are mainly due to dominant physio-pathological effects rather than fibre reconstruction intricacies. As a last note, a few studies have shown that the presence of a tumoral lesion may cause Wallerian degeneration to take place in the surrounding area and at distance from its location (Saksena et al 2013 ; Lahrmann et al 2005 ; Sawlani et al 1997 ). This physio-pathological process represents the inflammatory response of the nervous system to an axonal injury and may significantly impair the permeability of axons in those regions (Pierpaoli et al 2001 ), limiting the possibility for tractography algorithms to robustly reconstruct the associated streamlines.…”

Section: Discussionmentioning

confidence: 99%

Assessment of structural disconnections in gliomas: comparison of indirect and direct approaches

et al. 2022

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Gliomas are amongst the most common primary brain tumours in adults and are often associated with poor prognosis. Understanding the extent of white matter (WM) which is affected outside the tumoral lesion may be of paramount importance to explain cognitive deficits and the clinical progression of the disease. To this end, we explored both direct (i.e., tractography based) and indirect (i.e., atlas-based) approaches to quantifying WM structural disconnections in a cohort of 44 high- and low-grade glioma patients. While these methodologies have recently gained popularity in the context of stroke and other pathologies, to our knowledge, this is the first time they are applied in patients with brain tumours. More specifically, in this work, we present a quantitative comparison of the disconnection maps provided by the two methodologies by applying well-known metrics of spatial similarity, extension, and correlation. Given the important role the oedematous tissue plays in the physiopathology of tumours, we performed these analyses both by including and excluding it in the definition of the tumoral lesion. This was done to investigate possible differences determined by this choice. We found that direct and indirect approaches offer two distinct pictures of structural disconnections in patients affected by brain gliomas, presenting key differences in several regions of the brain. Following the outcomes of our analysis, we eventually discuss the strengths and pitfalls of these two approaches when applied in this critical field.

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Section: Discussionmentioning

confidence: 99%

Assessment of structural disconnections in gliomas: comparison of indirect and direct approaches

et al. 2022

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“…Thus, we believe this discretization step highlights in the nal SD maps those differences between the two approaches which are mainly due to dominant physio-pathological effects rather than bre reconstruction intricacies. As a last note, few studies have shown that the presence of a tumoral lesion may cause Wallerian degeneration to take place in the surrounding area and at distance from its location (Saksena et al 2013;Lahrmann et al 2005;Sawlani et al 1997). This physio-pathological process represents the in ammatory response of the nervous system to an axonal injury and may signi cantly impair the permeability of axons in those regions (Pierpaoli et al 2001), limiting the possibility for tractography algorithms to robustly reconstruct the associated streamlines.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Structural Disconnections In Gliomas: Comparison of Indirect And Direct Approaches

Silvestri

Villani

Moretto

et al. 2021

Preprint

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Gliomas are amongst the most common primary brain tumours in adults and are often associated with poor prognosis. Understanding the extent of white matter (WM) which is affected outside the tumoral lesion may be of paramount importance to explain cognitive deficits and the clinical progression of the disease. To this end, we explored both direct (i.e., tractography based) and indirect (i.e., atlas based) approaches to quantifying WM structural disconnections in a cohort of 50 high- and low-grade glioma patients. While these methodologies have recently gained popularity in the context of stroke, to our knowledge this is the first time they are applied in patients with brain tumours. More specifically, in this work we present a quantitative comparison of the disconnection maps provided by the two methodologies by applying well known metrics of spatial similarity, extension and correlation. Given the important role the oedematous tissue plays in the physiopathology of tumours, we performed these analyses both by including and excluding it in the definition of the tumoral lesion. This was done to investigate possible differences determined by this choice.We found that direct and indirect approaches offer two distinct pictures of structural disconnections in patients affected by brain gliomas, presenting key differences in several regions of the brain. Following the outcomes of our analysis, we eventually discuss the strengths and pitfalls of these two approaches when applied in this critical field.

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“…The degeneration of white matter (WM) fibres at a distance from a primary lesion, which is referred to as Wallerian degeneration (WD), is a common finding in many diseases of the central nervous system [1][2][3]. From the primary lesion, the WD proceeds distally towards the axon terminals.…”

Section: Introductionmentioning

confidence: 99%

“…In ischaemic stroke, the WD of the corticospinal tracts is a wellknown phenomenon [3,7]. However, only few studies have reported the WD in the pyramidal tracts in brain tumours [2,3]. The corpus callosum (CC) is the largest commissural fibre that connects the homologous regions of both the cerebral hemispheres of the brain and it plays a key role in the interhemispheric transfer of the sensory, motor and the cognitive information and the brain lateralization [8,9].…”

Section: Introductionmentioning

confidence: 99%

The Corpus Callosum Wallerian Degeneration in the Unilateral Brain Tumors: Evaluation with Diffusion Tensor Imaging (DTI)

Saksena

Jain

Schultz

et al. 2013

JCDR

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Purpose: The purpose of this study was to evaluate whether DTI could demonstrate the water diffusivity changes in the corpus callosum (CC), which were not visible on the morphologic imaging in patients with glioblastoma multiforme (GBM) and brain metastases with no midline CC infiltration. Materials and Methods:Twenty-seven patients with treatment naïve unilateral GBM and eleven patients with a solitary brain metastasis with no midline CC infiltration underwent DTI. Ten controls with normal brain MRI were also included. Based on the tensors, the principal diffusion directions, the anisotropy values, and the prior information about the diffusivity pattern in CC, a similarity measure was proposed. Subsequently, the CC was automatically divided into the Witelson subdivisions. Results:We observed significantly decreased fractional anisotropy values in all the regions of CC in the patients with GBM and metastases as compared to those in the controls. The mean diffusivity values showed a significant increase in all the regions of CC, except the splenium in patients with GBM and the isthmus in the patients with metastases, as compared to that in the controls respectively. Conclusion:In conclusion, DTI is more sensitive than the morphologic MR imaging in the evaluation of changes within the CC, in brain tumours which do not infiltrate the CC. However, these changes of the DTI metrics in the CC are due to a Wallerian degeneration rather than a tumour infiltration, as was shown by our results, as similar changes were seen in the GBM as well as the non-infiltrating metastases patients.

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Pyramidal tract degeneration in astrocytoma

Cited by 4 publications

References 3 publications

Assessment of structural disconnections in gliomas: comparison of indirect and direct approaches

Assessment of structural disconnections in gliomas: comparison of indirect and direct approaches

Assessment of Structural Disconnections In Gliomas: Comparison of Indirect And Direct Approaches

The Corpus Callosum Wallerian Degeneration in the Unilateral Brain Tumors: Evaluation with Diffusion Tensor Imaging (DTI)

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