The Corpus Callosum Wallerian Degeneration in the Unilateral Brain Tumors: Evaluation with Diffusion Tensor Imaging (DTI)

Saksena, Sona; Jain, Rajan; Schultz, Lonni; Jiang, Quan; Soltanian-Zadeh, Hamid; Scarpace, Lisa; Rosenblum, Mark L.; Mikkelsen, Tom; Nazem-Zadeh, Mohammad-Reza

doi:10.7860/jcdr/2013/4491.2757

Cited by 13 publications

(29 citation statements)

References 19 publications

(31 reference statements)

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“…For example, a previous histopathological study on postmortem brains showed that nerve fibers from inferior frontal and anterior inferior parietal regions course through the rostrum and genu, the fibers from superior frontal and anterior parietal regions course through the anterior two‐thirds of the body, and fibers from temporo‐parieto‐occipital regions course through the splenium and caudal body . In the last decade, DTI has revealed changes in the CC remote from the site of injury in the setting of cerebral infarction, tumor, epilepsy, and others . In a previous study, we demonstrated that DTI measurements from the CC not only can quantify tumor infiltration in patients with glioblastoma but can also predict overall survival .…”

Section: Corpus Callosummentioning

confidence: 80%

Wallerian Degeneration Beyond the Corticospinal Tracts: Conventional and Advanced MRI Findings

Chen

Nabavizadeh

Vossough

et al. 2016

Journal of Neuroimaging

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Wallerian degeneration (WD) is defined as progressive anterograde disintegration of axons and accompanying demyelination after an injury to the proximal axon or cell body. Since the 1980s and 1990s, conventional magnetic resonance imaging (MRI) sequences have been shown to be sensitive to changes of WD in the subacute to chronic phases. More recently, advanced MRI techniques, such as diffusion-weighted imaging (DWI) and diffusion tensor imaging (DTI), have demonstrated some of earliest changes attributed to acute WD, typically on the order of days. In addition, there is increasing evidence on the value of advanced MRI techniques in providing important prognostic information related to WD. This article reviews the utility of conventional and advanced MRI techniques for assessing WD, by focusing not only on the corticospinal tract but also other neural tracts less commonly thought of, including corticopontocerebellar tract, dentate-rubro-olivary pathway, posterior column of the spinal cord, corpus callosum, limbic circuit, and optic pathway. The basic anatomy of these neural pathways will be discussed, followed by a comprehensive review of existing literature supported by instructive clinical examples. The goal of this review is for readers to become more familiar with both conventional and advanced MRI findings of WD involving important neural pathways, as well as to illustrate increasing utility of advanced MRI techniques in providing important prognostic information for various pathologies.

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Section: Corpus Callosummentioning

confidence: 80%

Wallerian Degeneration Beyond the Corticospinal Tracts: Conventional and Advanced MRI Findings

Chen

Nabavizadeh

Vossough

et al. 2016

Journal of Neuroimaging

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“…The causes and time course of remote degeneration have been studied in many diseases (including stroke) via experimental procedures, pathology studies, and neuroimaging. 1–6 Knowledge of how disconnection caused by remote degeneration affects distant brain regions may be important, because losses in white matter (WM) integrity have been associated with functional deficits, including motor recovery after stroke. 3,7,8 Therefore, it may be helpful for clinicians to be able to predict which regions are susceptible to remote degeneration as it could enhance their prognostic abilities and enable more focused and individualized rehabilitative strategies.…”

Section: Introductionmentioning

confidence: 99%

Predicting Future Brain Tissue Loss From White Matter Connectivity Disruption in Ischemic Stroke

Kuceyeski

Kamel

Navi

et al. 2014

Stroke

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Background and Purpose The Network Modification (NeMo) Tool uses a library of brain connectivity maps from normal subjects to quantify the amount of structural connectivity loss caused by focal brain lesions. We hypothesized that the NeMo Tool could predict remote brain tissue loss caused by post-stroke loss of connectivity. Methods Baseline and follow-up MRIs (10.7±7.5 months apart) from 26 patients with acute ischemic stroke (age 74.6±14.1 years, initial NIH Stroke Scale 3.1±3.1) were collected. Lesion masks derived from diffusion-weighted images were superimposed on the NeMo Tool’s connectivity maps, and regional structural connectivity losses were estimated via the Change in Connectivity (ChaCo) score (i.e., the percent of tracks connecting to a given region that pass through the lesion mask). ChaCo scores were correlated with subsequent atrophy. Results Stroke lesions’ size and location varied, but they were more frequent in the left hemisphere. ChaCo scores, generally higher in regions near stroke lesions, reflected this lateralization and heterogeneity. ChaCo scores were highest in the postcentral and precentral gyri, insula, middle cingulate, thalami, putamen, caudate nuclei, and pallidum. Moderate, significant partial correlations were found between baseline ChaCo scores and measures of subsequent tissue loss (r=0.43, p=4.6×10−9; r=0.61, p=1.4×10−18), correcting for the time between scans. Conclusions ChaCo scores varied, but the most affected regions included those with sensorimotor, perception, learning and memory functions. Correlations between baseline ChaCo and subsequent tissue loss suggest that the NeMo Tool could be used to identify regions most susceptible to remote degeneration from acute infarcts.

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“…By contrast, WD showed a limited increase in diffusivity as there was neither formation of cysts nor significant water accumulation in the interstitial space. Studies have demonstrated WD in CC in brain tumors patients where tumors do not infiltrate the CC (48). Another imaging study of temporal lobe epilepsy showed changes not only in the seizure site, but also in remote locations such as the splenium of CC owing to secondary WD-mediated white matter degeneration (49).…”

Section: Discussionmentioning

confidence: 99%

Demonstration of Differentially Degenerated Corpus Callosam in Patients With Moderate Traumatic Brain Injury: With a Premise of Cortical-callosal Relationship

et al. 2015

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Background: Traumatic brain injury (TBI) has been shown to predominantly affect the corpus callosum (CC). In light of the anatomical organization of cortico-callosal connections, we hypothesized that injury to the different cortical lobes may specifically affect their corresponding subdivisional fibers in the CC. Objectives: The aim of this study was to investigate lesion-related Wallerian degeneration across the subdivisions of the CC in patients with moderate TBI. Patients and Methods: Diffusion tensor tractography (DTT) was performed between 14 days and 6 months after trauma in 18 patients with moderate TBI, and 11 age-and gender-matched healthy control subjects. Based on conventional magnetic resonance imaging findings, patients were classified into 3 groups: A) frontal lobe injury; B) occipito-temporal lobe injury; and C) fronto-parieto-temporal lobe injury. The CC was divided into seven subdivisions based on Witelson's classifications. Fractional anisotropy (FA) and mean diffusivity (MD) values from the seven segments were compared among patient groups and controls. Results: Compared to controls, Group A showed significantly reduced FA in the rostrum, genu, splenium, and CC. Group B showed significantly reduced FA in the isthmus and whole CC relative to that in the controls. In Group C, FA significantly decreased across the entire CC compared to that in the controls. Conclusions: In our study, subdivisional fibers of the CC showed secondary microstructural changes resulting from primary injury in the corresponding cortical areas. We conclude that DTT-derived measures may act as an indicator of ongoing Wallerian degeneration. By extension, this study may improve our understanding of variable neuropsychological outcomes in clinically similar patients with TBI.

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The Corpus Callosum Wallerian Degeneration in the Unilateral Brain Tumors: Evaluation with Diffusion Tensor Imaging (DTI)

Cited by 13 publications

References 19 publications

Wallerian Degeneration Beyond the Corticospinal Tracts: Conventional and Advanced MRI Findings

Wallerian Degeneration Beyond the Corticospinal Tracts: Conventional and Advanced MRI Findings

Predicting Future Brain Tissue Loss From White Matter Connectivity Disruption in Ischemic Stroke

Demonstration of Differentially Degenerated Corpus Callosam in Patients With Moderate Traumatic Brain Injury: With a Premise of Cortical-callosal Relationship

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