Pyospermia: background and controversies

Velez, Danielle; Ohlander, Samuel; Niederberger, Craig

doi:10.1016/j.xfre.2021.01.001

Cited by 15 publications

(21 citation statements)

References 23 publications

(16 reference statements)

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“…Another possible explanation is that the method and criteria of diagnosing leukocytospermia in some previous studies were different from those in a recent study. For example, Peroxidase staining is not regarded as the gold standard but the standard method for detecting semen leukocytes (Velez et al, 2021). However, Ricci et al revealed that leukocytospermia does not have significant negative effects on IVF or ICSI outcomes by using the method of flow cytometry to evaluate the effects of leukocytospermia even after adjusting the leukocytospermia cut‐off from 0.2 × 10 6 WBCs/ml to 2 × 10 6 WBCs/ml (Ricci et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Section: Ta B L Ementioning

confidence: 99%

“…Leukocytospermia is a common semen abnormality that accounts for 30% of male factor infertility (Brunner et al, 2019; Velez et al, 2021). According to the fifth World Health Organization (WHO) Laboratory Manual for the Examination and Processing of Human Semen, the presence of at least 1 × 10 6 peroxidase‐positive cells/ml in a semen sample is considered leukocytospermia (also known as Pyospermia; Ford, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Leukocytospermia, one of the common causes of male infertility, may adversely affect both sperm quality and fertilization (Lackner et al, 2010; Velez et al, 2021; Wolff et al, 1990). Many studies have investigated the relationships between semen quality and infertility (Castellini et al, 2020; Wolff et al, 1990; Yilmaz et al, 2005; Zorn et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Effects of leukocytospermia on the outcomes of assisted reproductive technology

Qiao

Zeng

et al. 2022

Andrologia

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Leukocytospermia is one of the common causes of male infertility, and its effects on the clinical outcomes of assisted reproduction are controversial. There are no recommendations for the management of leukocytospermia in cases of assisted reproductive technology (ART). To investigate the impact of leukocytospermia on ART, we retrospectively compared the clinical outcomes in ART couples with or without leukocytospermia and further analysed the impact of the insemination method itself by split insemination treatment in ART couples with leukocytospermia. In this study, leukocytospermia was detected in 133 patients, namely 63 in the conventional in vitro fertilization (IVF) group, 38 in the intracytoplasmic sperm injection (ICSI) group and 32 in the split insemination group. Leukocytospermia has a negative influence on the parameters of semen samples; however, leukocytospermia did not affect the clinical outcomes of IVF or ICSI. Different insemination methods did not affect the fertilization, clinical pregnancy or live birth rates. In the split insemination study, no significant differences in clinical pregnancy and live birth rates between the IVF and ICSI groups were found; however, the numbers of two pronuclei (2PN), available embryos and good‐quality embryos in the ICSI group were higher than those in the IVF group. Leukocytospermia may be a risk factor affecting semen parameters, and more attention should be given to IVF insemination. Leukocytospermia has no significant negative effect on the outcomes of ART. ICSI may obtain better embryos than IVF, but it cannot improve the clinical pregnancy and live birth rates.

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Section: Discussionmentioning

confidence: 99%

Section: Ta B L Ementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of leukocytospermia on the outcomes of assisted reproductive technology

Qiao

Zeng

et al. 2022

Andrologia

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“…Мужское бесплодие имеет мультифакториальный генез [1,2], в его развитии играют роль социальные, демографические, а также экологические факторы [3,4]. В условиях пандемии COVID-19 актуальным представляется исследование клинических особенностей и влияния вируса SARS-CoV-2 на репродуктивную систему и фертильность мужчин.…”

Section: Introductionunclassified

Chemiluminescence analysis of free radical processes in seminal plasma of men with pathospermia who have undergone COVID-19 infection

Курашова

Dashiev

Grebenkina

et al. 2022

Androl. genit. hir.

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Introduction. In the context of the COVID-19 pandemic, it seems relevant to study the clinical features and the effect of the SARS-CoV-2 virus on the reproductive system and male fertility.The study objective was to assess the intensity of oxidative processes in the seminal plasma of men with pathozoospermia after suffering a COVID-19 infection.Materials and methods. Spermogram parameters were assessed in accordance with the criteria of the 2010 WHO Guidelines, 5th edition, for the study and processing of human ejaculate two to three months after the patient received a negative polymerase chain reaction result of a nasopharyngeal swab for SARS-CoV-2 DNA. The intensity of free radical processes in seminal plasma was investigated by the method of chemiluminescence induced by ions of bivalent iron. Results. A decrease in sperm motility and an increase in the number of leukocytes were found in men with pathozoospermia who had undergone COVID-19 infection. There are lower levels of indicators such as ejaculate volume, total sperm concentration and the number of morphologically normal sperm forms. An increased ability to generate reactive oxygen species in seminal plasma was revealed in pathozoospermia and COVID-19.Conclusions. The results obtained indicate that SARS-CoV-2 affects the male reproductive system directly or indirectly and has a negative effect on male reproductive health, causing the activation of lipid peroxidation processes and spermatogenic insufficiency.

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Effect of leukocytes on semen quality in men from primary and secondary infertile couples: A cross‐sectional study

Fan,

Zhao,

Zhang

et al. 2023

Health Science Reports

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Background and AimsLeukocytospermia (LCS) is a known cause of male infertility. However, the relationship between seminal leukocytes and semen quality among infertile couples remains controversial. This study aims to investigate the association between semen quality and LCS in male partners of infertile couples.MethodsSemen samples were collected from 512 men who asked for a fertility evaluation in a reproductive center in China. Seminal leukocytes were counted following peroxidase staining with benzidine. Other semen parameters were compared in subfertile men with and without LCS.ResultsPoor semen quality (e.g., low semen volume, sperm concentration, and sperm progressive/total motility) was observed among men with LCS compared to those without LCS. Men with LCS had a higher risk of low sperm progressive motility (OR = 0.99, 95% CI = 0.98−0.99, p = 0.02) and total motility (OR = 0.99, 95% CI = 0.98−0.99, p = 0.02), even after adjustment for potential confounders (both OR = 0.99, 95% CI = 0.98−0.99, p = 0.03). Lower sperm viability was observed in LCS from male partners of secondary couples, while no significant difference in semen parameters was found between men with and without LCS in male partners of primary infertile couples. Low sperm motility and viability were associated with LCS in men from secondary infertile couples after adjusting for confounders (OR = 0.97, 95% CI = 0.95−0.99, p = 0.04; OR = 0.94, 95% CI = 0.89−0.99, p = 0.04, respectively).ConclusionsOur findings indicate that a higher risk of abnormal semen parameters was correlated with an increased number of leukocytes in men from secondary infertile couples.

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Pyospermia: background and controversies

Cited by 15 publications

References 23 publications

Effects of leukocytospermia on the outcomes of assisted reproductive technology

Effects of leukocytospermia on the outcomes of assisted reproductive technology

Chemiluminescence analysis of free radical processes in seminal plasma of men with pathospermia who have undergone COVID-19 infection

Effect of leukocytes on semen quality in men from primary and secondary infertile couples: A cross‐sectional study

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