Pyogranulomatous pleuropneumonia caused by Nocardia asiatica in a dog coinfected with canine morbillivirus (canine distemper virus)

Abstract

Nocardia asiatica causing pyogranulomatous pleuropneumonia is reported for the first time in a dog coinfected with canine morbillivirus (CM), diagnosed based on epidemiological, clinical, haematological, images, microbiological, histopathological, polymerase chain reaction and hsp65 gene sequencing findings. The immunosuppression of CM probably favoured the opportunistic behaviour of N. asiatica. Despite the therapeutic measures, the animal died, mainly due to respiratory distress. The association of methods to improve early diagnosis, therapy procedures and prognosis of canine nocardiosis is discussed, as well as the close relationship between pets and their owners, which may favour the transmission of pathogens such as Nocardia from pets‐to‐humans, which poses an emerging public health issue.

Disseminated Nocardiosis Caused by Nocardia farcinica in Two Puppy Siblings

“…Conversely, a primary pathogenic role has been proposed for canine nocardiosis where underlying causes are often unidentified [ 12 ]. However, putative predisposing factors have recently emerged, particularly co-infection with canine distemper virus [ 13 , 14 , 15 , 16 ] and treatment with immunosuppressants for the management of canine atopic dermatitis [ 17 , 18 , 19 ].…”

Protocolo pós-exposição ao vírus da Cinomose canina, com vacina de alta carga viral: Estudo observacional

“…Os sinais clínicos dependem da virulência da estirpe, condições ambientais, idade e status imunológico, sendo que os sistemas respiratório, gastrointestinal e neurológico, são os mais afetados (Duque-Valencia et al, 2019;Nardo et al, 2020). O vírus infecta diferentes tecidos, entre eles o tecido epitelial, mesenquimal, neuroendócrino e hematopoiético, produzindo assim sinais clínicos mais comuns como secreção nasal e ocular, erupções cutâneas, êmese e diarreia, leucoencefalomielite desmielinizante e a função imunológica do animal fica comprometida, devido a perda de linfócitos associada à replicação viral (Beineke et al, 2009;Nardo et al, 2020;Ribeiro et al, 2020).…”