Pyogenic granuloma, port-wine stain and pregnancy

Rodins, Karl; Gramp, Dallas; James, Daniel; Kumar, Sandeep

doi:10.1111/j.1440-0960.2010.00680.x

Cited by 13 publications

(11 citation statements)

References 9 publications

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“…We now add this body of evidence to our observations that PGAM5 depletion inhibited cell growth and increased the chemosensitivity of HCC in vivo and in vitro. Nearly every study of PGAM5 has provided evidence that it participates in early apoptotic events 37 , 38 . Consistently, our data revealed that PGAM5 knockdown enhanced apoptotic cell death.…”

Section: Discussionmentioning

confidence: 99%

High PGAM5 expression induces chemoresistance by enhancing Bcl-xL-mediated anti-apoptotic signaling and predicts poor prognosis in hepatocellular carcinoma patients

et al. 2018

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Hepatocellular carcinoma (HCC) is the one of most common and deadly cancers, and is also highly resistant to conventional chemotherapy treatments. Mitochondrial phosphoglycerate mutase/protein phosphatase (PGAM5) regulates mitochondrial homeostasis and cell death, however, little is known about its roles in cancer. The aim of this study was to explore the clinical significance and potential biological functions of PGAM5 in hepatocellular carcinoma. For the first time, our results show that PGAM5 is significantly upregulated in HCC compared with corresponding adjacent noncancerous hepatic tissues and high PGAM5 expression is an independent predictor of reduced survival times in both univariate and multivariate analyses. Additionally, in vivo and in vitro studies showed that depleting PGAM5 expression inhibited tumor growth and increased the 5-fluorouracil sensitivity of HCC cells. Conversely, restoring PGAM5 expression in PGAM5-knockdown cells dramatically enhanced HCC cell resistance to 5-fluorouracil. Importantly, we demonstrated that the mechanism of 5-fluorouracil resistance conferred to HCC cells by PGAM5 was via inhibiting BAX- and cytochrome C-mediated apoptotic signaling by interacting and stabilizing Bcl-xL. Consistently, in the same cohorts of HCC patient tissues, Bcl-xL expression was positively correlated with PGAM5, and together predicted poor prognoses. In Conclusion, Our data highlight the molecular etiology and clinical significance of PGAM5 in HCC. Targeting the novel signaling pathway mediated by PGAM5/Bcl-xL may represent a new therapeutic strategy to improve the survival outcomes of HCC patients.

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Section: Discussionmentioning

confidence: 99%

High PGAM5 expression induces chemoresistance by enhancing Bcl-xL-mediated anti-apoptotic signaling and predicts poor prognosis in hepatocellular carcinoma patients

et al. 2018

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“…Since there is a clear relationship between these entities, several authors have suggested that the increasing levels of circulant hormones such as progesterone and estrogens in pregnancy can exert the process of angiogenesis, decrease apoptosis in endothelial cells, and increased blood flow through the enlarged and ectatic vessels of PWS facilitating the delivery of pro-angiogenic factors and contributing for the development of PG [10,12]. A characteristic affection of gingival mucosa is consistent in most of the cases of co-occurrence during pregnancy [13][14][15]. Also, cases of PG have been shown to recur even in different anatomical locations with subsequent pregnancies [15].…”

Section: Discussionmentioning

confidence: 99%

An Uncommon Presentation of Pyogenic Granuloma

Luna‐Cerón¹,

Gómez-Gutiérrez²,

Gonzalez-Hernandez³

et al. 2021

Cureus

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Benign vascular neoplasms are common clinical problems encountered in the practice of primary care. Pyogenic granulomas are one of the most common benign vascular lesions in young adults. Although the physiopathological mechanism for the development of this condition is still not well understood, it has been commonly associated with several triggers such as treatment with retinoids, biological agents, invasive cutaneous therapies and trauma. The development of pyogenic granulomas on sites of vascular malformations like port wine stains has been described in the literature to occur rarely. Most of these types of cases have been studied to occur in the setting of pregnancy and after cryotherapy or pulsated laser therapy. The aim of this article is to present the case of a 21-year-old man with a recent appearance of a pyogenic granuloma within an underlying port wine stain in the posterior cervical region without any history of triggers or risk factors. Excision of the vascular lesion was done, and histopathological report confirmed the diagnosis. The objective of this manuscript is to discuss the possible mechanisms involved in the development of this uncommon presentation and to summarize the current literature related to this clinical scenario.

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“…13 In a similar way, after trauma, different angiogenic factors could stimulate endothelial proliferation leading to the development of a pyogenic granuloma. It is also known that pyogenic granulomas are a complication of certain vascular malformations, mainly capillary 14 and arteriovenous ones, 8,9 where they can develop spontaneously, during pregnancy, 14,15 or after a local injury including treatment with pulsed dye laser. 16 To our knowledge, pyogenic granulomas emerging over venous malformations has not been previously described.…”

Section: Discussionmentioning

confidence: 99%

Pyogenic granuloma over the venous component of a mixed vascular malformation

2019

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A 52‐year‐old man presented with a rapidly growing red tumor on the central neckline. It had appeared over a congenital flat and pinkish vascular lesion that involved the shoulder and the upper anterior area of his chest. Intermingled with the pinkish stain, there were also some blue nodules several millimeters in diameter. Histopathologic examination revealed that the full lesion was a mixed venous‐capillary malformation. The red tumor was excised and diagnosed as a pyogenic granuloma developing over the venous component of the vascular malformation. To our knowledge, a pyogenic granuloma growing over a venous malformation has not been previously described.

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Pyogenic granuloma, port-wine stain and pregnancy

Cited by 13 publications

References 9 publications

High PGAM5 expression induces chemoresistance by enhancing Bcl-xL-mediated anti-apoptotic signaling and predicts poor prognosis in hepatocellular carcinoma patients

High PGAM5 expression induces chemoresistance by enhancing Bcl-xL-mediated anti-apoptotic signaling and predicts poor prognosis in hepatocellular carcinoma patients

An Uncommon Presentation of Pyogenic Granuloma

Pyogenic granuloma over the venous component of a mixed vascular malformation

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