An Uncommon Presentation of Pyogenic Granuloma

Abstract

Benign vascular neoplasms are common clinical problems encountered in the practice of primary care. Pyogenic granulomas are one of the most common benign vascular lesions in young adults. Although the physiopathological mechanism for the development of this condition is still not well understood, it has been commonly associated with several triggers such as treatment with retinoids, biological agents, invasive cutaneous therapies and trauma. The development of pyogenic granulomas on sites of vascular malformations like port wine stains has been described in the literature to occur rarely. Most of these types of cases have been studied to occur in the setting of pregnancy and after cryotherapy or pulsated laser therapy. The aim of this article is to present the case of a 21-year-old man with a recent appearance of a pyogenic granuloma within an underlying port wine stain in the posterior cervical region without any history of triggers or risk factors. Excision of the vascular lesion was done, and histopathological report confirmed the diagnosis. The objective of this manuscript is to discuss the possible mechanisms involved in the development of this uncommon presentation and to summarize the current literature related to this clinical scenario.

Therapeutic endpoint determination using dermoscopy in pyogenic granuloma treatment with a pulsed dye laser in Republic of Korea: a case report

“…PG is a benign vascular neoplasm, histologically characterized by numerous proliferating vessels and small capillaries within fibrous and edematous stroma [3]. Although the exact pathogenesis has not been elucidated [1][2][3], an association with non-selective damage to skin components such as superficial blood vessels is hypothesized [4]. Inflammatory cell infiltration and endothelial proliferation stimulate the formation of granulation tissue and trigger abnormal angiogenesis [4].…”

“…Although the exact pathogenesis has not been elucidated [1][2][3], an association with non-selective damage to skin components such as superficial blood vessels is hypothesized [4]. Inflammatory cell infiltration and endothelial proliferation stimulate the formation of granulation tissue and trigger abnormal angiogenesis [4]. When laser treatment is considered for such vascular lesions, PDL remains the mainstay of treatment.…”

Concurrent Occurrence of Lobular Capillary Haemangioma and Port-Wine Stain: A Case Report and Literature Review

“…Port-wine stains also occur as bright red macules and characteristically do not cross the midline. Both lobular capillary haemangioma and port-wine stain have mutations in the G protein subunit alpha q (GNAQ), implying that lobular capillary haemangioma emerges from port-wine stain cells [ 20 ].…”