Pyogenic granuloma on the upper lip: an unusual location

Abstract

Pyogenic granuloma (PG) is a benign non-neoplastic mucocutaneous lesion. It is a reactional response to constant minor trauma and might be related to hormonal changes. In the mouth, PG is manifested as a sessile or pedunculated, resilient, erythematous, exophytic and painful papule or nodule with a smooth or lobulated surface that bleeds easily. PG preferentially affects the gingiva, but may also occur on the lips, tongue, oral mucosa and palate. The most common treatment is surgical excision. This paper describes a mucocutaneous PG on the upper lip, analyzing the clinical characteristics and discussing the features that distinguish this lesion from other similar oral mucosa lesions. The diagnosis of oral lesions is complex and leads the dentist to consider distinct lesions with different diagnostic methods. This case report with a 4 year-follow-up calls the attention to the uncommon mucocutaneous labial location of PG and to the fact that surgical excision is the safest method for diagnosis and treatment of PG of the lip, even when involving the mucosa and skin

Agreement between clinical and histopathologic diagnoses and completeness of oral biopsy forms

“…In our study, those cases corresponded to inflammatory hyperplasia and pyogenic granuloma, which eventually develop an irregular or lobulated surface, mimicking a papilloma 29,30 . However, this misdiagnosis was not implicated in different therapeutic approaches because such lesions are treated by surgical excision.…”

Pyogenic Granuloma on the Upper Labial Mucosa: A Case Report

“…There is a relatively high rate of recurrence (about 16%) after a simple excision. Recurrences after surgeries of the extragingival pyogenic granuloma are however uncommon [2,6,[8][9][10].…”

Granulome pyogénique palatin chez une femme enceinte

“…Le granulome pyogénique siége rarement sur le palais dur [5][6][7][8]. La localisation gingivale représente plus de 75 % des cas rapportés [9][10][11][12].…”

“…La localisation gingivale représente plus de 75 % des cas rapportés [9][10][11][12]. La pathologie peut être retrouvée à tous les âges mais elle est plus fréquente lors des deuxième et troisième décennies [4,6,8,10]. Sa prévalence chez la femme enceinte varie entre 5 et 8 % [1,10].…”

“…En effet, ces hormones stimulent l'expression des facteurs angiogéniques dans les tissus enflammatoires. Ces facteurs qui ont un rôle important dans la morphogénèse vasculaire, sont retrouvés en quantité importante dans les granulomes pyogéniques pendant la grossesse et en faible quantité après l'accouchement [1,6,8,15]. Parmi les facteurs angiogéniques, on retrouve : -le facteur de croissance de l'endothélium vasculaire (VEGF) ; -le facteur de croissance dérivé des plaquettes sanguines (PDGF) ; -le facteur de croissance des fibroblastes (bFGF) ; -l'angiopoïétine 1 et 2 (Ang-1, Ang-2).…”