“…Based on the scientific evidence, estrogen can trigger nerve growth factor, fibroblast growth factor, Granulocyte macrophage-colony stimulating factor which ultimately forms granulation tissue. (6,7,8) Majority of the lesions (75%)of lesions occurs in interdental papillae, followed by lower lip, tongue, palate and buccal mucosa. (9) The clinical presentation is usually as a pedunculated smooth or lobulated warty mass, color ranges from pink to red purple.…”