Pyoderma gangrenosum with extensive perianal involvement

Abstract

CASE REPORT71-year-old male with no personal events of interest was admitted to the emergency department due to a large perianal ulcer with gluteus extension of 1 month of evolution and multiple inguinoscrotal ulcers of later onset (Fig. 1). The patient denies sexual intercourse the previous months and had not consulted earlier because of shame, but due to progression of ulcers and increasing pain he went to the emergency department. On digital rectal examination anal, sphincter maintained good tone and feces without pathological products were palpated in rectal ampulla.In the emergency department, we made sampling for culture and biopsy of ulcers and wound cleansing. The serological tests for HIV, HBV, HCV, syphilis and VZV were negative. Histopathological study showed areas of ulceration in the epidermis and inflammatory infiltrate in dermis.Colonoscopy and pelvic MRI showed no relevant findings. He was valued by dermatology department and a exclusion iagnosis of ulcerated pyoderma gangrenosum without associated systemic disease was established. Topical treatment with 2% cromoglycate and 0.1% protopic ointment (tacrolimus) and oral prednisone was indicated. He was discharged at 2 months after admission with partial reepithelization of the lesions. At one year follow-up, the patient showed almost complete reepithelization of the lesions (Fig. 2). Pyoderma gangrenosum with extensive perianal involvement

Pyoderma gangrenosum faciale in a patient with Crohn's disease

“…1,2 We found 2 other cases of perianal PG after conducting a PubMed review using the terms ''Pyoderma gangrenosum AND perianal.'' 4,5 Because PG is associated with an underlying disease in 50% to 78% of patients, most commonly IBD, investigation into a comorbid condition is warranted. 6 Endoscopic and histologic confirmation of IBD may be difficult in patients presenting with acute PG due to intolerance of or inadequate bowel preparation, timing of immunosuppressive therapies that blunt diagnostic sensitivity of gastrointestinal histology, and gastroenterologist willingness to pursue invasive tests in the absence of symptoms.…”

Perianal pyoderma gangrenosum after excision and fulguration of anal condyloma acuminatum

“…There has been one case report of perianal pyoderma gangrenosum in the Spanish literature of a 71-year-old male without any significant surgical or medical history. The patient presented with extensive, painful perianal ulcers that were successfully treated with tacrolimus and oral prednisone [15] . This case was one of idiopathic pyoderma gangrenosum and was not provoked by trauma.…”