“…1,2 We found 2 other cases of perianal PG after conducting a PubMed review using the terms ''Pyoderma gangrenosum AND perianal.'' 4,5 Because PG is associated with an underlying disease in 50% to 78% of patients, most commonly IBD, investigation into a comorbid condition is warranted. 6 Endoscopic and histologic confirmation of IBD may be difficult in patients presenting with acute PG due to intolerance of or inadequate bowel preparation, timing of immunosuppressive therapies that blunt diagnostic sensitivity of gastrointestinal histology, and gastroenterologist willingness to pursue invasive tests in the absence of symptoms.…”