Pyoderma Gangrenosum in Ulcerative Colitis

Two Cases of Pyoderma (Ecthyma) Gangraenosum Associated with the Presence of an Abnormal Serumprotein (β₂A-paraprotein)

“…This fact is reported in at least 9 cases out of 53 patients of the first group. These cases are not different from the rest in any other respect, three of them have arthritis and the morphology of the ulcers conforms to the picture in the other patients [51,13,64,48,73,32,9,55], (b) In the second group of 10, 4 patients with this sym ptom are described [29,26,55).…”

“…In one case [30] sterile pus was found on puncturing. In four cases the involvem ent of the joints is styled as " arthritis" [11,30,32,55], in one case as acute rheum atism [38] and in another case as early osteoarthrosis [40]. To this total of 12 patients out of 53, a num ber of the cases of Perry and Brunsting [55] should perhaps be added, as these authors fail to indicate in 6 of their cases suffering from arthritis whether or not they had colitis ulcerosa.…”

“…(a) The simultaneous im provem ent and relapse of sym ptom s of colitis ulcerosa and pyoderma gangraenosum and sometimes of ar thritis as well is mentioned for at least 34 of the 53 patients of the first group [51,11,13,48,73,30,17,12,32,20,70,61,55,54,15,45,27,41,39,71].…”

Pyoderma Gangrenosum*

“…Clinical Features.-The type of primary lesion is probably variable, many patients being first seen with established ulceration in whom further ulcers do not develop and thus reveal the earUest lesions in their particular case* The primary lesion has frequently been observed as a vesicle or pustule. Kiel (1947) found the contents of such a primary vesicle to be sterile. This observation was repeated in one of the patients reported herein (Mrs. E.) upon a lai^e vesicle two inches (five centimetres) across and two days old.…”