Pyoderma gangrenosum cutanéomuqueux et systémique

Poiraud, C.; Gagey-Caron, V.; Barbarot, S.; Durant, C.; Ayari, Sameh; Stalder, J.‐F.

doi:10.1016/j.annder.2010.01.007

Cited by 14 publications

(8 citation statements)

References 15 publications

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“…Lesions on the lips can exhibit crusting [16,29]. Supplementary images of oral PG ulcers showing the variety of morphologic features can be visualized in the case reports [5,10,[20][21][22][23]29]. Oral and skin lesions in PG are non-indurated.…”

Section: Discussion Oral Manifestations Of Pgmentioning

confidence: 99%

“…The most frequent sites were the tongue, buccal mucosa and soft palate, together representing 67.6% (23/34) of all reported oral lesions. Other lesions involved the hard palate, oropharynx, lip, commissure, gingiva, and retromolar area [5,14,16,17,19,20]. Generally, mucosal lesions in the oral cavity were smaller than skin lesions, measuring between 1 and 5 cm in greatest diameter [5,14,18,[21][22][23][24][25][26][27].…”

Section: Discussion Oral Manifestations Of Pgmentioning

confidence: 99%

“…Reports of extensive ulceration bordered by an overlying fibrinopurulent membrane with heavy neutrophilic infiltration of the lamina propria are consistently seen in biopsied cases [5,12,16,18,23,24,26,[29][30][31][32]. Neutrophils can have an altered appearance [20]. A mixed inflammatory cell infiltrate comprised of polymorphonuclear neutrophils, lymphocytes, histiocytes, and plasma cells is also reported.…”

Section: Histopathologymentioning

confidence: 99%

“…Elevated erythrocyte sedimentation rate (ESR) [5,17,27,29] and C-reactive protein [20][21][22]30] have been observed in cases of oral PG. Blood work can be useful to exclude infectious causes and sexually transmitted diseases (ex.…”

Section: Underlying Systemic Diseases Associated With Pgmentioning

confidence: 99%

See 3 more Smart Citations

Oral Pyoderma Gangrenosum: Diagnosis, Treatment and Challenges: A Systematic Review

Bissonnette

Kauzman

Mainville

2017

Head and Neck Pathol

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Section: Discussion Oral Manifestations Of Pgmentioning

confidence: 99%

Section: Discussion Oral Manifestations Of Pgmentioning

confidence: 99%

Section: Histopathologymentioning

confidence: 99%

Section: Underlying Systemic Diseases Associated With Pgmentioning

confidence: 99%

See 2 more Smart Citations

Oral Pyoderma Gangrenosum: Diagnosis, Treatment and Challenges: A Systematic Review

Bissonnette

Kauzman

Mainville

2017

Head and Neck Pathol

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“…Other particular forms have also been described: peristomal, genital, mucosal, extracutaneous, and postoperative [8–11]. Herein, the authors present a patient with postoperative PG in association with renal cell carcinoma and chronic lymphocytic leukemia.…”

Section: Introductionmentioning

confidence: 99%

Postoperative Pyoderma Gangrenosum in Association with Renal Cell Carcinoma and Chronic Lymphocytic Leukemia

et al. 2013

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IntroductionPyoderma gangrenosum (PG) is a rare sterile neutrophilic dermatosis characterized by painful recurrent ulcerations. It is frequently associated with inflammatory bowel disease, rheumatoid arthritis, or malignancies. PG is a diagnosis of exclusion, and it is based on clinical presentation, histology, history of an underlying disease, and exclusion of other causes of ulceration.Case ReportThe authors report a 62-year-old male who developed a nonhealing ulcer at the site of incision following nephrectomy for renal cell carcinoma. Past medical history included chronic lymphocytic leukemia treated with rituximab. Histology of the skin lesion showed a phlegmonous nonspecific inflammation without being able to differentiate between a necrotizing wound infection and PG. The patient’s condition was initially diagnosed as an infectious process and treated accordingly. After unsuccessful results with systemic antibiotics, high-dose corticosteroids induced prompt healing of the wound. On these bases, the diagnosis of postoperative PG within chronic lymphocytic leukemia and renal cell carcinoma was made.ConclusionFaced with postoperative necrotizing ulceration resistant to correctly administered antibiotics, PG must be considered. In such condition, the diagnosis must not be guided primarily by histology and early advice of a dermatologist is recommended.

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