Dressing changes for chronic wounds are associated with high levels of physical and psychological stress for the patient. The nurse’s primary responsibility is to minimize the stress factors associated with dressing changes or to manage them professionally. The article will focus on the pathophysiology of the wounds and the choice of dressing material. Using the examples of wounds in Pyoderma gangraenosum (PG), Livedo-Vasculopathy (LV) and Caliphylaxis (CP), which are extremely painful at the onset of the disease, I would like to demonstrate ways of minimizing pain in wounds based on the pathophysiology of the wounds.