Pyoderma gangrenosum: A review

Schwaegerle, Sonya Martin; Bergfeld, Wilma F.; Senitzer, David; Tidrick, Robert T.

doi:10.1016/s0190-9622(88)70080-8

Cited by 140 publications

(77 citation statements)

References 60 publications

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“…The clinical and pathologic pattern seen in our study most closely resembles that of pyoderma gangrenosum, a rare ulcerating skin disease of unknown cause (Schwaegerle et al, 1988;Weiss, 1989). Typically, pyoderma gangrenosum begins as small erythematous papules that spread concentrically.…”

Section: Oka Et Alsupporting

confidence: 68%

Interleukin-8 Overexpression Is Present in Pyoderma Gangrenosum Ulcers and Leads to Ulcer Formation in Human Skin Xenografts

Oka

Berking

Nesbit

et al. 2000

Laboratory Investigation

113

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SUMMARY: ) is a potent chemotactic polypeptide for neutrophils. However, the role of this cytokine during inflammation remains unclear. Skin specimens from patients with pyoderma gangrenosum demonstrated IL-8 overexpression in skin ulcers, which suggests a role for IL-8 in the development of the disease. We therefore constructed a recombinant adenovirus expressing the complementary deoxyribonucleic acid encoding human IL-8 (IL-8/Ad5) that induces a 2000-fold increase in IL-8 expression of infected human fibroblasts in vitro. Human skin engrafted to severe combined immunodeficiency mice and then injected with the recombinant virus demonstrated erythema, an intense perivascular infiltration of neutrophils, and extravasation of erythrocytes after 8 hours. By 12 hours after injection, neutrophils had accumulated beneath the epidermis, which then necrotized, and one or more ulcers that remained for approximately 2 weeks were observed. Clinically and histologically, the ulcers resembled pyoderma gangrenosum. These clinical and experimental findings suggest an etiologic role of IL-8 in the pathogenesis of pyoderma gangrenosum. (Lab Invest 2000, 80:595-604).

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Section: Oka Et Alsupporting

confidence: 68%

Interleukin-8 Overexpression Is Present in Pyoderma Gangrenosum Ulcers and Leads to Ulcer Formation in Human Skin Xenografts

Oka

Berking

Nesbit

et al. 2000

Laboratory Investigation

113

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“…İyileşen lezyonların yerlerinde sikatris kalır (Resim 9). Sıklıkla romatolojik hastalıklar, inflamatuvar barsak hastalıkları ve monoklonal gamopatilerle ilişkili olabilir [74][75][76][77][78] . Püstüler form ise sıklıkla inflamatuvar barsak hastalıkları ile ilişkili olup, etrafı eritemli halo ile çevrili multipl steril, simetrik püstüllerle karakterizedir 62,64,73 .…”

Section: Subkorneal Püstüler Dermatozunclassified

“…www.turk derm.org.tr Türk derm 2013; 47: özel sayı 2: [69][70][71][72][73][74][75][76][77] Ekinci ve ark. Paraneoplastik özellik gösteren reaktif dermatozlar ilişkilendirilen 3 ana formu bulunmaktadır.…”

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Paraneoplastik özellik gösteren reaktif dermatozlar

Ekinci¹,

Aslan²

2013

TURKDERM

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ÖzetReaktif dermatozlar infeksiyonlar, inflamatuar hastalıklar, ilaç kullanımı ve maligniteler başta olmak üzere birçok nedenle ortaya çıkabilirler. Böyle bir dermatozla karşılaşan hekimler dermatozu tedavi etmenin yanı sıra altta yatan nedeni araştırmaya da yönelirler. Bu derlemede, reaktif dermatozların paraneoplastik potansiyelleri değerlendirilerek tanı sonrası etyoloji, takip ve tedavide yapılması gerekenler irdelenmiştir. Sum maryReactive dermatoses may occur related to many underlying causes including infections, inflammatory diseases, medications and malignancies. In the management of these dermatoses the investigation of underlying cause is crucial besides the therapy of dermatosis. In this review, mainly the paraneoplastic potentials of reactive dermatoses have been evaluated and additionally the etiology, follow-up and treatment have been discussed. Recent literature about figurated erythemas (erythema annulare centrifugum, erythema gyratum repens, necrolytic migratory erythema), neutrophilic dermatoses (Sweet's syndrome, pyoderma gangrenosum, subcorneal pustular dermatosis) and erythema nodosum have been scrutinized. (Turkderm 2013; 47: Suppl 2: 69-77) Key Words: Paraneoplasia, reactive dermatoses, Sweet syndrome, erythema gyratum repens, necrolytic migratory erythema, erythema annulare centrifugum, subcorneal pustular dermatosis, erythema nodosum, pyoderma gangrenosum

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“…Pyoderma gangrenosum (PG) is a type of inflammatory skin condition of unknown origin characterized by progressive and recurrent skin ulceration of destructive course [1][2][3] . Dermatosis is usually unpredictable, sudden and aggressive, but it can also be chronic, slow and insidious, presenting skin ulcers that expand centrifugally 4 .…”

Section: Introductionmentioning

confidence: 99%

Pyoderma gangrenosum as a initial manifestation of ulcerative proctocolitis

Fonseca¹,

Motta²,

Rampazzo³

et al. 2011

J. Coloproctol. (Rio J.)

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301FONSECA CB, MOTTA GL, RAMPAZZO A, JUNIOR JCC, FAGUNDES RB. Pyoderma gangrenosum as a initial manifestation of ulcerative proctocolitis. Rev bras Coloproct, 2011;31(3): 301-305.AbstRACt: pyoderma gangrenosum is a rare inflammatory skin condition characterized by progressive and recurrent skin ulceration of destructive course. It is usually associated with rheumatoid arthritis, paraproteinemia, myeloproliferative diseases and inflammatory bowel diseases, especially non-specific ulcerative proctocolitis. In these situations, skin lesions are described as concurrent with the intestinal condition. However, reports on pyoderma gangrenosum preceding intestinal findings are less frequent. The authors describe a case of a woman with febrile condition associated with skin lesions diagnosed by biopsy as pyoderma gangrenosum. Two weeks later, she developed diarrhea, arthralgia and sepsis, being diagnosed as ulcerative proctocolitis. After the administration of the treatment for ulcerative proctocolitis, she showed improvements in sepsis care, remission of diarrhea and regression of skin lesions. This case highlights the importance of considering pyoderma gangrenosum as a manifestation associated with inflammatory bowel disease, regardless of its timing in relation to intestinal symptoms.

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Pyoderma gangrenosum: A review

Cited by 140 publications

References 60 publications

Interleukin-8 Overexpression Is Present in Pyoderma Gangrenosum Ulcers and Leads to Ulcer Formation in Human Skin Xenografts

Interleukin-8 Overexpression Is Present in Pyoderma Gangrenosum Ulcers and Leads to Ulcer Formation in Human Skin Xenografts

Paraneoplastik özellik gösteren reaktif dermatozlar

Pyoderma gangrenosum as a initial manifestation of ulcerative proctocolitis

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