Pygospio elegans (Annelida: Spionidae) — an annelid model for regeneration studies

Starunov, Viktor V.; Barmasova, G. A.; Nesterenko, Maksim A.; Kulakova, Milana A.; Novikova, Elena L.

doi:10.15298/invertzool.17.3.04

Cited by 7 publications

(24 citation statements)

References 33 publications

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“…This difference is explained by different modes of anterior and posterior regeneration. The posterior regeneration is in fact restricted to reconstitution of the pygidium and the growth zone, while the anterior one is related with redevelopment of the full set of lost thoracic segments in addition to the prostomium (44). The difference in nervous system regeneration in different body parts re ects the overall difference in anterior and posterior body segments regeneration.…”

Section: Regenerationmentioning

confidence: 99%

“…Pygospio elegans is a tube-dwelling worm belonging to one of the largest annelid families Spionidae, widely distributed in intertidal sand ats in bays and estuaries of the Arctic Ocean and northern regions of the Paci c and Atlantic oceans as well (43,44). Its small size and outstanding regenerative capacities make P. elegans a perspective annelid model to study reparative processes (44). The general morphology of anterior and posterior regeneration after traumatic amputation or asexual reproduction of P. elegans is well described (45,46).…”

Section: Introductionmentioning

confidence: 99%

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Histamine and gamma-aminobutyric acid in the nervous system of Pygospio elegans (Annelida: Spionidae): structure and recovery during reparative regeneration

Starunova¹,

Shunkina²,

Novikova³

et al. 2022

BMC Zool

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Background In recent two decades, studies of the annelid nervous systems were revolutionized by modern cell labeling techniques and state-of-the-art microscopy techniques. However, there are still huge gaps in our knowledge on the organization and functioning of their nervous system. Most of the recent studies have focused on the distribution of serotonin and FMRFamide, while the data about many other basic neurotransmitters such as histamine (HA) and gamma-aminobutyric acid (GABA) are scarce. Results Using immunohistochemistry and confocal microscopy we studied the distribution of histamine and gamma-aminobutyric acid in the nervous system of a spionid annelid Pygospio elegans and traced their redevelopment during reparative regeneration. Both neurotransmitters show specific patterns in central and peripheral nervous systems. HA-positive cells are concentrated mostly in the brain, while GABA-positive cell somata contribute equally to brain and segmental ganglia. Some immunoreactive elements were found in peripheral nerves. Both substances were revealed in high numbers in bipolar sensory cells in the palps. The first signs of regenerating HAergic and GABAergic systems were detected only by 3 days after the amputation. Further redevelopment of GABAergic system proceeds faster than that of HAergic one. Conclusions Comparisons with other annelids and mollusks examined in this respect revealed a number of general similarities in distribution patterns of HAergic and GABAergic cells in different species. Overall, the differences in the full redevelopment of various neurotransmitters correlate with neuronal development during embryogenesis. Our results highlight the importance of investigating the distribution of different neurotransmitters in comparative morphological and developmental studies.

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Section: Regenerationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Histamine and gamma-aminobutyric acid in the nervous system of Pygospio elegans (Annelida: Spionidae): structure and recovery during reparative regeneration

Starunova¹,

Shunkina²,

Novikova³

et al. 2022

BMC Zool

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“…Although the first stages of wound healing can occur in the absence of innervation [80,81], the neurites are crucial for the initiation and growth of the blastema and morphogenesis [20,65,82]. By the time the regeneration blastema appears, the neurites may form a different number of more or less thick nerves, terminating at the site of pygidial or prostomial appendages formation [78,79,83,84]. Lateral nerves of the VNC often join in a loop, which is typical of anterior regeneration [85][86][87][88][89][90] but also occurs in the case of posterior regeneration.…”

Section: Nervous Systemmentioning

confidence: 99%

“…The epimorphic processes of the muscle layer reconstruction have received much attention, in part due to the development of staining methods with labeled phalloidin and confocal microscopy [33,38,79,84,88,89,146,147]. Muscle precursors (mesodermal cells of the blastema) accumulate mainly in the ventral and lateral parts of the regenerative bud, between the intestine and the epidermis.…”

Section: Coelom Wall and Muscular Systemmentioning

confidence: 99%

“…Nevertheless, several ultrastructural studies indicate that the muscles of the body wall regenerate from a common blastemal material [31,37,140]. The circular, transverse, and parapodial muscles develop later than the longitudinal ones; in posterior regeneration, an anterior-to-posterior gradient of their initiation and maturation is apparent [38,79,84,89,146]. Myofibers of myoepithelial cells of dissepiments, mesentery, and intestinal wall differentiate simultaneously with those of the somatic muscles.…”

Section: Coelom Wall and Muscular Systemmentioning

confidence: 99%

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Comparative Aspects of Annelid Regeneration: Towards Understanding the Mechanisms of Regeneration

Kostyuchenko

Kozin

2021

Genes

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The question of why animals vary in their ability to regenerate remains one of the most intriguing questions in biology. Annelids are a large and diverse phylum, many members of which are capable of extensive regeneration such as regrowth of a complete head or tail and whole-body regeneration, even from few segments. On the other hand, some representatives of both of the two major annelid clades show very limited tissue regeneration and are completely incapable of segmental regeneration. Here we review experimental and descriptive data on annelid regeneration, obtained at different levels of organization, from data on organs and tissues to intracellular and transcriptomic data. Understanding the variety of the cellular and molecular basis of regeneration in annelids can help one to address important questions about the role of stem/dedifferentiated cells and “molecular morphallaxis” in annelid regeneration as well as the evolution of regeneration in general.

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About Regeneration of Alien Polychaete Polydora websteri (Annelida: Spionidae)

Lisitskaya

Boltachova

2021

Russ J Biol Invasions

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Pygospio elegans (Annelida: Spionidae) — an annelid model for regeneration studies

Cited by 7 publications

References 33 publications

Histamine and gamma-aminobutyric acid in the nervous system of Pygospio elegans (Annelida: Spionidae): structure and recovery during reparative regeneration

Histamine and gamma-aminobutyric acid in the nervous system of Pygospio elegans (Annelida: Spionidae): structure and recovery during reparative regeneration

Comparative Aspects of Annelid Regeneration: Towards Understanding the Mechanisms of Regeneration

About Regeneration of Alien Polychaete Polydora websteri (Annelida: Spionidae)

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