Pycnidiophorones A–D, four new cytochalasans from the wetland derived fungus <i>Pycnidiophora dispersa</i>

Zhao, Chen; Liu, Gaoran; Liu, Xingzhong; Zhang, Lan; Li, Lin; Liu, Ling

doi:10.1039/d0ra08072a

Cited by 3 publications

(4 citation statements)

References 27 publications

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“…PSU-RSPG185 Surat Thani Province, Thailand - [ 30 ] 57*, 58 Iizukines C-D Aspergillus iizukae Shandong Province, China Cytotoxicity [ 31 ] 59 MBJ-0030 Stachybotrys sp. f23793 Shizuoka prefecture, Japan - [ 32 ] 60 MBJ-0031 61 MBJ-0032 62*, 63*, 64*, 65* Pycnidiophorones A-D Pycnidiophora dispersa Hebei Province, China Cytotoxicity [ 33 ] 66* Clonorosin A Clonostachys rosea Bank of the Yellow River in Lanzhou, Gansu, China Active (66*) against Fusarium oxysporum [ 34 ] 67 Clonorosin B Bank of the Yellow River in Lanzhou, Gansu, China 68*, 69*, 70*, 71*, 72*, 73* Gymnastatins T-Y Gymnascella dankaliensis Giza pyramids, Egypt Cytotoxicity [ 35 ] 74* Dankastatin D 75 N -[4-hydroxy-3-prenyl-benzoyl]-L-threonine Curvularia inaequalis strain HS-FG-257 Heilongjiang Province, China - [ 36 ] 76 N -[2,2-dimethyl-2 H -...…”

Section: Concluding Remarks and Discussionmentioning

confidence: 99%

“… 89 Compounds 62 – 6 5 showed moderate cytotoxicity against five tested human tumor cell lines: HeLa, PC-3, A549, HepG-2 and HL-60. 33 Pyrenosetin D 543 showed toxicity towards both A-375 and HaCaT cells with IC 50 values of 77.5 and 39.3 μM, respectively. 165 Compounds 165,166 , and 168 exhibited moderate cytotoxic activities with IC50 values ranging from 18.4 to 29.4 μM.…”

Section: Biological Activity Of New Compounds Derived From Soil Fungimentioning

confidence: 97%

“… 32 Pycnidiophorones A-D 62 – 65 ( Figure 2E ) were isolated from cultures of the wetland-soil-derived fungus Pycnidiophora dispersa. 33 Clonorosins A 66 and B 67 ( Figure 2E ), two novel indole alkaloids featuring unprecedented 6/5/6/6/5 and 6/5/5 cores, were isolated from the soil-derived fungus Clonostachys rosea YRS-06. 34 …”

Section: Structure Types Of New Compounds Derived From Soil Fungimentioning

confidence: 99%

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The Novel Compounds with Biological Activity Derived from Soil Fungi in the Past Decade

Zhang¹,

Li²,

Fan³

et al. 2022

DDDT

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The secondary metabolites isolated from soil fungi have received more and more attention, especially new compounds that exhibited good biological activities. In this review, a total of 546 new compounds are included in the relevant literature since 2011. The new compounds are isolated from soil fungi, We divided these compounds into seven categories, including alkaloids, terpenoids, steroids, ketones, phenylpropanoids, quinones, esters, lactones, etc. In addition, the biological activities and structure–activity relationships of these compounds have also been fully discussed. The activities of these compounds are roughly divided into eight categories, including anticancer activity, antimicrobial activity, anti-inflammatory activity, antioxidant activity, antiviral activity, antimalarial activity, immunosuppressive activity and other activities. Since natural products are an important source of new drugs, this review may have a positive guiding effect on drug screening.

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Section: Concluding Remarks and Discussionmentioning

confidence: 99%

Section: Biological Activity Of New Compounds Derived From Soil Fungimentioning

confidence: 97%

Section: Structure Types Of New Compounds Derived From Soil Fungimentioning

confidence: 99%

See 1 more Smart Citation

The Novel Compounds with Biological Activity Derived from Soil Fungi in the Past Decade

Zhang¹,

Li²,

Fan³

et al. 2022

DDDT

View full text Add to dashboard Cite

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“…Compounds 112 – 114 and 165 – 167 separated from the culture of wetland-soil-associated Pycnidiophora dispersa , utilizing SiO 2 /RP-18 CC/HPLC had cytotoxic capacity against HeLa, PC-3, A549, HepG-2, and HL-60 (IC 50 s ranged from 11.4 to 86.8 μM) compared to cisplatin (IC 50 s ranging from 5.6 to 15.7 μM) in the CCK-8 assay. Compounds 112 and 165 had marked efficacy on A549 cells (IC 50 s 13.0 and 11.4 μM, respectively) compared to cisplatin (IC 50 11.8 μM) ( Zhao et al, 2020 ).…”

Section: Bioactivities Of Depsidonesmentioning

confidence: 99%

Recent advances on natural depsidones: sources, biosynthesis, structure-activity relationship, and bioactivities

Khayat

Ghazawi

Samman

et al. 2023

PeerJ

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Depsidones are a class of polyphenolic polyketides that have been proposed to be biosynthesized from oxidative coupling of esters of two polyketidic benzoic acid derivatives. They are principally encountered in fungi and lichens. In addition to their diversified structural features, they revealed varied bioactivities such as antimicrobial, antimalarial, cytotoxic, anti-inflammatory, anti-Helicobacter pylori, antimycobacterial, antihypertensive, anti-diarrheal, antidiabetic, phytotoxic, anti-HIV, anti-osteoclastogenic, and butyrylcholinesterase, tyrosinase, hyaluronidase, and acetylcholinesterase inhibition. The current work was targeted to provide an overview on the naturally reported depsidones from various sources in the period from 2018 to the end of 2022 including their structures, biosynthesis, sources, and bioactivities, as well as the reported structure-activity relationship and semisynthetic derivatives. A total of 172 metabolites with 87 references were reviewed. The reported findings unambiguously demonstrated that these derivatives could be promising leads for therapeutic agents. However, further in-vivo evaluation of their potential biological properties and mechanistic investigations are needed.

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Integrative Genomics and Bioactivity-Guided Isolation of Novel Antimicrobial Compounds from Streptomyces sp. KN37 in Agricultural Applications

Zhao,

Li,

Zeeshan

et al. 2024

Molecules

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Actinomycetes have long been recognized as an important source of antibacterial natural products. In recent years, actinomycetes in extreme environments have become one of the main research directions. Streptomyces sp. KN37 was isolated from the cold region of Kanas in Xinjiang. It demonstrated potent antimicrobial activity, but the primary active compounds remained unclear. Therefore, we aimed to combine genomics with traditional isolation methods to obtain bioactive compounds from the strain KN37. Whole-genome sequencing and KEGG enrichment analysis indicated that KN37 possesses the potential for synthesizing secondary metabolites, and 41 biosynthetic gene clusters were predicted, some of which showed high similarity to known gene clusters responsible for the biosynthesis of antimicrobial antibiotics. The traditional isolation methods and activity-guided fractionation were employed to isolate and purify seven compounds with strong bioactivity from the fermentation broth of the strain KN37. These compounds were identified as 4-(Diethylamino)salicylaldehyde (1), 4-Nitrosodiphenylamine (2), N-(2,4-Dimethylphenyl)formamide (3), 4-Nitrocatechol (4), Methylsuccinic acid (5), Phenyllactic acid (6) and 5,6-Dimethylbenzimidazole (7). Moreover, 4-(Diethylamino)salicylaldehyde exhibited the most potent inhibitory effect against Rhizoctonia solani, with an EC50 value of 14.487 mg/L, while 4-Nitrosodiphenylamine showed great antibacterial activity against Erwinia amylovora, with an EC50 value of 5.715 mg/L. This study successfully isolated several highly active antimicrobial compounds from the metabolites of the strain KN37, which could contribute as scaffolds for subsequent chemical synthesis. On the other hand, the newly predicted antibiotic-like substances have not yet been isolated, but they still hold significant research value. They are instructive in the study of active natural product biosynthetic pathways, activation of silent gene clusters, and engineering bacteria construction.

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Pycnidiophorones A–D, four new cytochalasans from the wetland derived fungus Pycnidiophora dispersa

Abstract: Four new 5/6/6/5/6 pentacyclic cytochalasan pycnidiophorones A–D (1–4) and six known depsidones were identified from the wetland-soil-derived fungus Pycnidiophora dispersa.

Cited by 3 publications

References 27 publications

The Novel Compounds with Biological Activity Derived from Soil Fungi in the Past Decade

The Novel Compounds with Biological Activity Derived from Soil Fungi in the Past Decade

Recent advances on natural depsidones: sources, biosynthesis, structure-activity relationship, and bioactivities

Integrative Genomics and Bioactivity-Guided Isolation of Novel Antimicrobial Compounds from Streptomyces sp. KN37 in Agricultural Applications

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