PWE-098 Risk stratification and non-invasive monitoring of patients with parenteral nutrition associated liver disease

Mansour, Diana; Gemell, L; Byrne, Christopher D.; Masson, Steven; Bannon, M; Mountford, C; Leyland, H.; Thompson, NP

doi:10.1136/gutjnl-2017-314472.344

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“…PN is subassigned into total parenteral nutrition (TPN) and supplementary parenteral nutrition (SPN) [20]. TPN refers to when patients with gastrointestinal dysfunction or failure, cannot be enteral nutrition or do not allow enteral nutrition, through the central vein, or peripheral intravenous infusion of necessary nutrients to meet the comprehensive metabolic needs.…”

Section: Discussionmentioning

confidence: 99%

Effects of Adipose Plasma Transfusion Compared with Normal Plasma Transfusion on Adverse Transfusion Reactions, Important Functional Indicators, and Clinical Safety in Patients with Parenteral Nutrition: Based on a Retrospective Cohort Study

Gong

Qin

Chen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. Based on a retrospective cohort study, the study aims to investigate the effects of adipose plasma transfusion compared with normal plasma transfusion on adverse transfusion reactions, important functional indicators, and clinical safety in patients with parenteral nutrition (PN). Methods. One hundred and twenty inpatients who needed PN and plasma transfusion in Xianning Central Hospital from September 1, 2021, to March 31, 2022, were enrolled as the actual application verification cases. All the patients in the group noticed the informed consent form, and the normal plasma transfusion was set as the control group (n = 40), and the fat plasma transfusion was set as the study group. Mild adipose plasma transfusion was adopted in study group ① and moderate adipose plasma transfusion was used in study group ②, 40 cases in each group. The blood routine tests, blood lipids, blood coagulation, liver function tests, and the incidence of adverse reactions of blood transfusion were compared. Results. The comparison results of platelet count, red blood cell count, hemoglobin, and hematocrit among the three groups are as follows: study group ②> study group ①> control group ( P < 0.05 ).The levels of blood lipids in the three groups, triglyceride, total cholesterol, high density lipoprotein, and low density lipoprotein were compared in group ②>group ①>control group ( P < 0.05 ).The liver function tests indexes of the three groups were compared: ALT, AST, LDH: study ②<study ①<control group; ALP: study ②>study ①>control group. Regarding the incidence of adverse transfusion reactions, the incidence of adverse transfusion reactions in the study group was lower than in the control group ( P < 0.05 ). Conclusion. Compared with normal plasma transfusion, the inpatients who need PN and plasma transfusion can effectively use the scrapped mild and moderate fatty plasma and reduce the plasma scrap rate. In the meantime, it has little effect on the function of the important indexes of the patients, and the incidence of adverse reactions of blood transfusion is low and the safety is high. Infusion of adipose plasma can also improve the effective individual and rational utilization of blood products. Trial registration: This trial is registered with chiCTR220005918.

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Section: Discussionmentioning

confidence: 99%