PVP/corticosteroid microspheres produced by supercritical antisolvent coprecipitation

Prosapio, Valentina; Marco, Iolanda De; Reverchon, Ernesto

doi:10.1016/j.cej.2016.02.041

Cited by 64 publications

(40 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are various SCF-assisted micronization techniques based on SC-CO 2 behavior, and the supercritical antisolvent (SAS) process has been successfully used to prepare nanodosage forms of drugs (their polymeric composites in pharmaceutical formulations) [32][33][34]. In general, in the SAS process, solutes (drugs) are dissolved in organic solvents, and then the organic solvent and SC-CO 2 diffuse into each other, leading to the occurrence of a high degree of supersaturation and the eventual precipitation of the solutes.…”

Section: Introductionmentioning

confidence: 99%

“…Poly (vinyl pyrrolidone) (PVP) is one such hydrophilic synthetic polymer, and it is widely used as a carrier in the fabrication of controlled release systems to enhance the dissolution rate and solubility of poorly water-soluble drugs. Moreover, PVP is an excellent polymer (with the properties of biodegradability, biosafety, and biocompatibility) and has been promising in several pharmaceutical applications, such as wound dressing [38], tissue engineering [39], and drug delivery [33]. Because PVP retards crystal growth and stabilizes solids in a high-energy state, it is highly suitable as a biocompatible polymer in coprecipitating crystalline drugs [40].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fabrication of Supercritical Antisolvent (SAS) Process-Assisted Fisetin-Encapsulated Poly (Vinyl Pyrrolidone) (PVP) Nanocomposites for Improved Anticancer Therapy

Chen

et al. 2020

Nanomaterials

View full text Add to dashboard Cite

Due to its hydrophobicity, fisetin (FIS) often suffers from several limitations in terms of its applicability during the fabrication of pharmaceutical formulations. To overcome this intrinsic limitation of hydrophobicity, we demonstrate here the generation of poly (vinyl pyrrolidone) (PVP)-encapsulated FIS nanoparticles (FIS-PVP NPs) utilizing a supercritical antisolvent (SAS) method to enhance its aqueous solubility and substantial therapeutic effects. In this context, the effects of various processing and formulation parameters, including the solvent/antisolvent ratio, drug/polymer (FIS/PVP) mass ratio, and solution flow rate, on the eventual particle size as well as on distribution were investigated using a 23 factorial experimental design. Notably, the FIS/PVP mass ratio significantly affected the morphological attributes of the resultant particles. Initially, the designed constructs were characterized systematically using various techniques (e.g., chemical functionalities were examined with Fourier-transform infrared (FTIR) spectroscopy, and physical states were examined with X-ray diffraction analysis (XRD) and differential scanning calorimetry (DSC) techniques). In addition, drug release as well as cytotoxicity evaluations in vitro indicated that the nanosized polymer-coated particles showed augmented performance efficiency compared to the free drug, which was attributable to the improvement in the dissolution rate of the FIS-PVP NPs due to their small size, facilitating a higher surface area over the raw form of FIS. Our findings show that the designed SAS process-assisted nanoconstructs with augmented bioavailability, have great potential for applications in pharmaceutics.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fabrication of Supercritical Antisolvent (SAS) Process-Assisted Fisetin-Encapsulated Poly (Vinyl Pyrrolidone) (PVP) Nanocomposites for Improved Anticancer Therapy

Chen

et al. 2020

Nanomaterials

View full text Add to dashboard Cite

show abstract

“…In particular, PVP has been used as a hydrophilic carrier, as it tends to improve the dissolution rate of the active compound, as widely demonstrated in the literature. [15,24,[32][33][34][35][36][37][38] In contrast, zein has been chosen for its ability to prolong drug release due to its hydrophobic behaviour. [30,31,39,40] In summary, PVP can be suitable for improving the dissolution rate of poorly water-soluble NSAIDs, while zein can prolong the release of antibiotics, for which a reduction in the frequency of administrations is desirable.…”

Section: Introductionmentioning

confidence: 99%

Supercritical antisolvent coprecipitation in the pharmaceutical field: Different polymeric carriers for different drug releases

Franco

Marco

2020

Can J Chem Eng

Self Cite

View full text Add to dashboard Cite

The supercritical antisolvent process (SAS) was employed to obtain polymer/drug coprecipitated powders. Indeed, processes based on the use of supercritical fluids allow us to obtain polymer/active drug coprecipitated microparticles with tunable bioavailability. In this work, two different biocompatible polymers were selected to be used as carriers for obtaining drug microparticles with different releases for different applications: polyvinylpyrrolidone (PVP) was coprecipitated with ketoprofen to obtain a rapid drug release and zein was coprecipitated with ampicillin to obtain a controlled drug release. The experiments were performed both on a bench‐scale and a pilot‐scale plant. Ketoprofen is one of the most prescribed non‐steroidal anti‐inflammatory drugs. It is poorly soluble in water and, to overcome this inconvenience, in this work, it was coprecipitated with PVP. In correspondence with the optimized polymer/drug ratio, the dissolution rate of the active principle in the coprecipitated particles was about three times higher than the one of the unprocessed ketoprofen. The second model drug under study in this paper is ampicillin, a semi‐synthetic penicillin that is one of the most commonly prescribed broad‐spectrum antibiotics. Prolonging the release of the drug would imply a reduction in the number of administrations and, therefore, of the side effects associated with too high dosages. For this purpose, in this work, ampicillin was coprecipitated with zein. Zein/ampicillin microparticles were produced up to a polymer/drug ratio of 5/1 w/w; in this case, the antibiotic coprecipitated with zein reaches 90% of its dissolution in about 14 hours, while the unprocessed antibiotic takes about 3 hours to dissolve.

show abstract

“…Supercritical fluid‐assisted techniques have gained interest due to the unique properties of supercritical fluids (SCFs). SCFs show, at the same time, liquid‐like properties and gas‐like properties which can be tuned according to the employed pressure and the temperature , . Carbon dioxide (CO 2 ) is the most used fluid since it has a relatively accessible critical point, i.e., 304.25 K and 7.38 MPa, which makes it useful for the processing of thermosensitive compounds; moreover, it is nonflammable, nontoxic, noncorrosive, inexpensive, and can be easily recycled .…”

Section: Introductionmentioning

confidence: 99%

Design of a Cost‐Reduced Flexible Plant for Supercritical Fluid‐Assisted Applications

et al. 2018

Self Cite

View full text Add to dashboard Cite

A novel batch plant for supercritical CO 2 applications is proposed which is not equipped with expensive components, such as high-pressure pumps, making it particularly suitable for bench-scale use. For the first time, the use of a hanging scale is suggested to weigh the amount of CO 2 required for the experiment and the use of the thermodynamics to reach the working conditions. The rig is able to cover different applications, e.g., aerogel drying, impregnation, and extraction, showing high flexibility. An approximate cost analysis has been performed considering as a reference a 150-mL vessel. It has been calculated that both the setup and running costs are considerably lower than the common batch and semicontinuous rigs.

show abstract

PVP/corticosteroid microspheres produced by supercritical antisolvent coprecipitation

Cited by 64 publications

References 52 publications

Fabrication of Supercritical Antisolvent (SAS) Process-Assisted Fisetin-Encapsulated Poly (Vinyl Pyrrolidone) (PVP) Nanocomposites for Improved Anticancer Therapy

Fabrication of Supercritical Antisolvent (SAS) Process-Assisted Fisetin-Encapsulated Poly (Vinyl Pyrrolidone) (PVP) Nanocomposites for Improved Anticancer Therapy

Supercritical antisolvent coprecipitation in the pharmaceutical field: Different polymeric carriers for different drug releases

Design of a Cost‐Reduced Flexible Plant for Supercritical Fluid‐Assisted Applications

Contact Info

Product

Resources

About